Essential role of placental leucine aminopeptidase in gynecologic malignancy

Shigehiko Mizutani; Kiyosumi Shibata; Fumitaka Kikkawa; Akira Hattori; Masafumi Tsujimoto; Masakazu Ishii; Hiroshi Kobayashi

doi:10.1517/14728222.11.4.453

Essential role of placental leucine aminopeptidase in gynecologic malignancy

Shigehiko Mizutani, Kiyosumi Shibata, Fumitaka Kikkawa, Akira Hattori, Masafumi Tsujimoto, Masakazu Ishii, Hiroshi Kobayashi

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

Original language	English
Pages (from-to)	453-461
Number of pages	9
Journal	Expert Opinion on Therapeutic Targets
Volume	11
Issue number	4
DOIs	https://doi.org/10.1517/14728222.11.4.453
Publication status	Published - 04-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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abstract = "The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.",

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AU - Mizutani, Shigehiko

AU - Shibata, Kiyosumi

AU - Kikkawa, Fumitaka

AU - Hattori, Akira

AU - Tsujimoto, Masafumi

AU - Ishii, Masakazu

AU - Kobayashi, Hiroshi

PY - 2007/4

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AB - The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

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Essential role of placental leucine aminopeptidase in gynecologic malignancy

Abstract

All Science Journal Classification (ASJC) codes

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