Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function

Hisashi Hashimoto; Atsumi Kojima; Tamotsu Sudo; Noriyoshi Ohki; Satoshi Yamaguchi; Yoshiki Mikami; Masaharu Ito; Ryuichiro Nishimura

doi:10.1111/j.1749-0774.2008.00051.x

Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function

Hisashi Hashimoto, Atsumi Kojima, Tamotsu Sudo, Noriyoshi Ohki, Satoshi Yamaguchi, Yoshiki Mikami, Masaharu Ito, Ryuichiro Nishimura

Research output: Contribution to journal › Article › peer-review

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Abstract

Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.

Original language	English
Pages (from-to)	64-69
Number of pages	6
Journal	Human Cell
Volume	21
Issue number	3
DOIs	https://doi.org/10.1111/j.1749-0774.2008.00051.x
Publication status	Published - 08-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cell Biology
Cancer Research

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10.1111/j.1749-0774.2008.00051.x

Cite this

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title = "Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function",

abstract = "Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.",

author = "Hisashi Hashimoto and Atsumi Kojima and Tamotsu Sudo and Noriyoshi Ohki and Satoshi Yamaguchi and Yoshiki Mikami and Masaharu Ito and Ryuichiro Nishimura",

year = "2008",

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doi = "10.1111/j.1749-0774.2008.00051.x",

language = "English",

volume = "21",

pages = "64--69",

journal = "Human Cell",

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TY - JOUR

T1 - Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function

AU - Hashimoto, Hisashi

AU - Kojima, Atsumi

AU - Sudo, Tamotsu

AU - Ohki, Noriyoshi

AU - Yamaguchi, Satoshi

AU - Mikami, Yoshiki

AU - Ito, Masaharu

AU - Nishimura, Ryuichiro

PY - 2008/8

Y1 - 2008/8

N2 - Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.

AB - Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma.

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JO - Human Cell

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ER -

Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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