Establishment of a monitoring system to detect inhibition of mRNA processing

Ken Ichi Fujita, Masumi Okamura, Sachiko Nishimoto, Tomoya Kurihara, Keiko Momma, Yusaku Miyamae, Taiho Kambe, Masaya Nagao, Hiroshi Narita, Seiji Masuda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound, spliceostatin A (SSA), which inhibits mRNA splicing. This system should serve to facilitate the discovery of novel compounds from natural resources that inhibit mRNA processing.

Original languageEnglish
Pages (from-to)1248-1251
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number6
DOIs
Publication statusPublished - 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Establishment of a monitoring system to detect inhibition of mRNA processing'. Together they form a unique fingerprint.

Cite this