Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

Tomokazu Umezu, Hiroaki Kajiyama, Mikio Terauchi, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Fumitaka Kikkawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 ng/mL, 2.4 μg/mL and 32.5 μg/mL, respectively. The NOE cells expressed estrogen receptor α. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalHuman Cell
Volume20
Issue number3
DOIs
Publication statusPublished - 01-08-2007

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Cancer Research

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