Establishment of a normal reference value for serum β2 microglobulin in Japanese children

Reevaluation of its clinical usefulness

Yohei Ikezumi, Masataka Honda, Takeshi Matsuyama, Kenji Ishikura, Hiroshi Hataya, Nahoko Yata, Takuhito Nagai, Naoya Fujita, Shuichi Ito, Kazumoto Iijima, Tetsuji Kaneko, Osamu Uemura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Serum β2 microglobulin (β2MG) is considered to be a marker of renal function, which is independently associated with age. However, only a few studies have reported the reference values for β2MG in children thus far, particularly in young children. In this study, we evaluated the distribution of serum β2MG values in healthy Japanese children and assessed its clinical usefulness. Method: The normal reference value of serum β2MG was assessed in serum samples from 1131 normal Japanese children (504 boys and 627 girls; age 0-17 years). To test the validity of the reference value, serum samples from children with various kidney diseases were also examined retrospectively. Results: The mean values for β2MG were significantly negatively correlated with age (r = -0.47, P < 0.001). No significant difference was observed between the values of boys and girls in any age group. The established β2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length. Conclusion: The newly established β2MG reference value in children can be used to detect kidney impairment in children. Serum β2MG in combination with serum Cr used as markers for predicting glomerular function can provide an accurate detection of kidney dysfunction in children.

Original languageEnglish
Pages (from-to)99-105
Number of pages7
JournalClinical and Experimental Nephrology
Volume17
Issue number1
DOIs
Publication statusPublished - 01-02-2013

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Reference Values
Serum
Kidney
Creatinine
Kidney Diseases
Age Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Ikezumi, Yohei ; Honda, Masataka ; Matsuyama, Takeshi ; Ishikura, Kenji ; Hataya, Hiroshi ; Yata, Nahoko ; Nagai, Takuhito ; Fujita, Naoya ; Ito, Shuichi ; Iijima, Kazumoto ; Kaneko, Tetsuji ; Uemura, Osamu. / Establishment of a normal reference value for serum β2 microglobulin in Japanese children : Reevaluation of its clinical usefulness. In: Clinical and Experimental Nephrology. 2013 ; Vol. 17, No. 1. pp. 99-105.
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abstract = "Objective: Serum β2 microglobulin (β2MG) is considered to be a marker of renal function, which is independently associated with age. However, only a few studies have reported the reference values for β2MG in children thus far, particularly in young children. In this study, we evaluated the distribution of serum β2MG values in healthy Japanese children and assessed its clinical usefulness. Method: The normal reference value of serum β2MG was assessed in serum samples from 1131 normal Japanese children (504 boys and 627 girls; age 0-17 years). To test the validity of the reference value, serum samples from children with various kidney diseases were also examined retrospectively. Results: The mean values for β2MG were significantly negatively correlated with age (r = -0.47, P < 0.001). No significant difference was observed between the values of boys and girls in any age group. The established β2MG reference range covered 99.7 {\%} of patients with decreased kidney function below 75 {\%} based on their serum creatinine (Cr) value and body length. Conclusion: The newly established β2MG reference value in children can be used to detect kidney impairment in children. Serum β2MG in combination with serum Cr used as markers for predicting glomerular function can provide an accurate detection of kidney dysfunction in children.",
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Ikezumi, Y, Honda, M, Matsuyama, T, Ishikura, K, Hataya, H, Yata, N, Nagai, T, Fujita, N, Ito, S, Iijima, K, Kaneko, T & Uemura, O 2013, 'Establishment of a normal reference value for serum β2 microglobulin in Japanese children: Reevaluation of its clinical usefulness', Clinical and Experimental Nephrology, vol. 17, no. 1, pp. 99-105. https://doi.org/10.1007/s10157-012-0658-7

Establishment of a normal reference value for serum β2 microglobulin in Japanese children : Reevaluation of its clinical usefulness. / Ikezumi, Yohei; Honda, Masataka; Matsuyama, Takeshi; Ishikura, Kenji; Hataya, Hiroshi; Yata, Nahoko; Nagai, Takuhito; Fujita, Naoya; Ito, Shuichi; Iijima, Kazumoto; Kaneko, Tetsuji; Uemura, Osamu.

In: Clinical and Experimental Nephrology, Vol. 17, No. 1, 01.02.2013, p. 99-105.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Establishment of a normal reference value for serum β2 microglobulin in Japanese children

T2 - Reevaluation of its clinical usefulness

AU - Ikezumi, Yohei

AU - Honda, Masataka

AU - Matsuyama, Takeshi

AU - Ishikura, Kenji

AU - Hataya, Hiroshi

AU - Yata, Nahoko

AU - Nagai, Takuhito

AU - Fujita, Naoya

AU - Ito, Shuichi

AU - Iijima, Kazumoto

AU - Kaneko, Tetsuji

AU - Uemura, Osamu

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Objective: Serum β2 microglobulin (β2MG) is considered to be a marker of renal function, which is independently associated with age. However, only a few studies have reported the reference values for β2MG in children thus far, particularly in young children. In this study, we evaluated the distribution of serum β2MG values in healthy Japanese children and assessed its clinical usefulness. Method: The normal reference value of serum β2MG was assessed in serum samples from 1131 normal Japanese children (504 boys and 627 girls; age 0-17 years). To test the validity of the reference value, serum samples from children with various kidney diseases were also examined retrospectively. Results: The mean values for β2MG were significantly negatively correlated with age (r = -0.47, P < 0.001). No significant difference was observed between the values of boys and girls in any age group. The established β2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length. Conclusion: The newly established β2MG reference value in children can be used to detect kidney impairment in children. Serum β2MG in combination with serum Cr used as markers for predicting glomerular function can provide an accurate detection of kidney dysfunction in children.

AB - Objective: Serum β2 microglobulin (β2MG) is considered to be a marker of renal function, which is independently associated with age. However, only a few studies have reported the reference values for β2MG in children thus far, particularly in young children. In this study, we evaluated the distribution of serum β2MG values in healthy Japanese children and assessed its clinical usefulness. Method: The normal reference value of serum β2MG was assessed in serum samples from 1131 normal Japanese children (504 boys and 627 girls; age 0-17 years). To test the validity of the reference value, serum samples from children with various kidney diseases were also examined retrospectively. Results: The mean values for β2MG were significantly negatively correlated with age (r = -0.47, P < 0.001). No significant difference was observed between the values of boys and girls in any age group. The established β2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length. Conclusion: The newly established β2MG reference value in children can be used to detect kidney impairment in children. Serum β2MG in combination with serum Cr used as markers for predicting glomerular function can provide an accurate detection of kidney dysfunction in children.

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