Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1

Mutsushi Matsuyama, Kazuo Kato, Kyoko Moriguchi, Tetsuji Yamada, Takashi Kuramoto, Makoto Kuroda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To confirm the presence of the susceptible gene for the thymoma development in the region that was assumed by the previous linkage study by Oyabu et al. (J Natl Cancer Inst 91:279-282, 1999), we tried to establish a congenic strain of rats. Methods: Backcrossings between the BUF/Mna strain as a donor strain and the ACI/NMna strain as an inbred partner were repeated for 12 generations, examining whether rats had the thymoma development region, and then homozygous rats were yielded by mating among the heterozygotes. To detect the phenotypic expression, heterozygous ACI.BUF/Mna-Tsr1/+ (ACI-Tsr1/+) rats were generated by crossing female ACI.BUF/Mna-Tsr1/Tsr1 (ACI-Tsr1/Tsr1) rats with male ACI/NMna rats and were maintained for 24 months. Results: These ACI-Tsr1/+ rats produced thymoma in 71%, showing a dominant trait. The thymomas were of the lymphocyte predominant type, as those developed in rats of the original BUF/Mna strain. Conclusions: Thus, a new rat congenic strain, ACI-Tsr1/Tsr1, was established, revealing that thymoma develops in the dominant trait in ACI-Tsr1/+ rats.

Original languageEnglish
Pages (from-to)789-792
Number of pages4
JournalJournal of Cancer Research and Clinical Oncology
Volume134
Issue number7
DOIs
Publication statusPublished - 01-07-2008

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Inbred ACI Rats
Thymoma
Inbred BUF Rats
Inbreeding
Heterozygote
Lymphocytes
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Matsuyama, Mutsushi ; Kato, Kazuo ; Moriguchi, Kyoko ; Yamada, Tetsuji ; Kuramoto, Takashi ; Kuroda, Makoto. / Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1. In: Journal of Cancer Research and Clinical Oncology. 2008 ; Vol. 134, No. 7. pp. 789-792.
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abstract = "Purpose: To confirm the presence of the susceptible gene for the thymoma development in the region that was assumed by the previous linkage study by Oyabu et al. (J Natl Cancer Inst 91:279-282, 1999), we tried to establish a congenic strain of rats. Methods: Backcrossings between the BUF/Mna strain as a donor strain and the ACI/NMna strain as an inbred partner were repeated for 12 generations, examining whether rats had the thymoma development region, and then homozygous rats were yielded by mating among the heterozygotes. To detect the phenotypic expression, heterozygous ACI.BUF/Mna-Tsr1/+ (ACI-Tsr1/+) rats were generated by crossing female ACI.BUF/Mna-Tsr1/Tsr1 (ACI-Tsr1/Tsr1) rats with male ACI/NMna rats and were maintained for 24 months. Results: These ACI-Tsr1/+ rats produced thymoma in 71{\%}, showing a dominant trait. The thymomas were of the lymphocyte predominant type, as those developed in rats of the original BUF/Mna strain. Conclusions: Thus, a new rat congenic strain, ACI-Tsr1/Tsr1, was established, revealing that thymoma develops in the dominant trait in ACI-Tsr1/+ rats.",
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Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1. / Matsuyama, Mutsushi; Kato, Kazuo; Moriguchi, Kyoko; Yamada, Tetsuji; Kuramoto, Takashi; Kuroda, Makoto.

In: Journal of Cancer Research and Clinical Oncology, Vol. 134, No. 7, 01.07.2008, p. 789-792.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Establishment of thymoma-prone congenic rat strain, ACI.BUF/Mna-Tsr1/Tsr1

AU - Matsuyama, Mutsushi

AU - Kato, Kazuo

AU - Moriguchi, Kyoko

AU - Yamada, Tetsuji

AU - Kuramoto, Takashi

AU - Kuroda, Makoto

PY - 2008/7/1

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N2 - Purpose: To confirm the presence of the susceptible gene for the thymoma development in the region that was assumed by the previous linkage study by Oyabu et al. (J Natl Cancer Inst 91:279-282, 1999), we tried to establish a congenic strain of rats. Methods: Backcrossings between the BUF/Mna strain as a donor strain and the ACI/NMna strain as an inbred partner were repeated for 12 generations, examining whether rats had the thymoma development region, and then homozygous rats were yielded by mating among the heterozygotes. To detect the phenotypic expression, heterozygous ACI.BUF/Mna-Tsr1/+ (ACI-Tsr1/+) rats were generated by crossing female ACI.BUF/Mna-Tsr1/Tsr1 (ACI-Tsr1/Tsr1) rats with male ACI/NMna rats and were maintained for 24 months. Results: These ACI-Tsr1/+ rats produced thymoma in 71%, showing a dominant trait. The thymomas were of the lymphocyte predominant type, as those developed in rats of the original BUF/Mna strain. Conclusions: Thus, a new rat congenic strain, ACI-Tsr1/Tsr1, was established, revealing that thymoma develops in the dominant trait in ACI-Tsr1/+ rats.

AB - Purpose: To confirm the presence of the susceptible gene for the thymoma development in the region that was assumed by the previous linkage study by Oyabu et al. (J Natl Cancer Inst 91:279-282, 1999), we tried to establish a congenic strain of rats. Methods: Backcrossings between the BUF/Mna strain as a donor strain and the ACI/NMna strain as an inbred partner were repeated for 12 generations, examining whether rats had the thymoma development region, and then homozygous rats were yielded by mating among the heterozygotes. To detect the phenotypic expression, heterozygous ACI.BUF/Mna-Tsr1/+ (ACI-Tsr1/+) rats were generated by crossing female ACI.BUF/Mna-Tsr1/Tsr1 (ACI-Tsr1/Tsr1) rats with male ACI/NMna rats and were maintained for 24 months. Results: These ACI-Tsr1/+ rats produced thymoma in 71%, showing a dominant trait. The thymomas were of the lymphocyte predominant type, as those developed in rats of the original BUF/Mna strain. Conclusions: Thus, a new rat congenic strain, ACI-Tsr1/Tsr1, was established, revealing that thymoma develops in the dominant trait in ACI-Tsr1/+ rats.

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