Estrogen producing ovarian fibrosarcoma: A case report

Mayo Miura, Shiro Suzuki, Kiyosumi Shibata, Hiroaki Kajiyama, Fumitaka Kikkawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Fibrosarcoma is an extremely rare malignant sex-cord stromal tumor. Fibrosarcoma is generally unknown as an estrogen producing tumor. This report presents, for the first time, a case of estrogen producing ovarian fibrosarcoma in an 83-year-old female. We performed total hysterectomy, bilateral salpingo-oophorectomy and omentectomy. Histopathologically, the tumor of the left ovary had high cellularity, cellular atypia and 10-15 mitotic counts per 10 high power fields. The tumor contained small components composed of cells that were similar to Sertoli cells. In an effort to examine which component was producing estrogen, we checked aromatase expression; but both components were positive. We could not explain which component was producing estrogen. Postoperative clinical stage was IA. As she was geriatric patient, we did not recommend adjuvant chemotherapy. There were no signs of recurrence or increase in serum estradiol level at two years after the operation.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalNagoya journal of medical science
Issue number1
Publication statusPublished - 01-02-2019

All Science Journal Classification (ASJC) codes

  • General Medicine


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