Etoposide-related acute promyelocytic leukemia

K. Kudo, H. Yoshida, H. Kiyoi, S. Numata, K. Horibe, T. Naoe

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44 Citations (Scopus)


The development of therapy-related acute myeloid leukemia (t-AML) has become a growing concern over the past decade, because of the increase in the percentage of long-term survivors of primary malignancy. We reviewed 17 cases with etoposide-related acute promyelocytic leukemia (APL) reported in the literature. The close association between treatment with etoposide for Langerhans cell histiocytosis (LCH) and the development of etoposide-related APL was demonstrated among Japanese and Italians. Our data on the breakpoints (b/ps) of the PML and RARα genes are presented. It is suggested that chromatin structure might be more important than specific consensus sequence in the distribution of b/ps in etoposide-related APL.

Original languageEnglish
Pages (from-to)1171-1175
Number of pages5
Issue number8
Publication statusPublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research


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