Evaluating genetic risk for prostate cancer among Japanese and Latinos

Iona Cheng, Gary K. Chen, Hidewaki Nakagawa, Jing He, Peggy Wan, Cathy C. Laurie, Jess Shen, Xin Sheng, Loreall C. Pooler, Andrew T. Crenshaw, Daniel B. Mirel, Atsushi Takahashi, Michiaki Kubo, Yusuke Nakamura, Ali Amin Al Olama, Sara Benlloch, Jenny L. Donovan, Michelle Guy, Freddie C. Hamdy, Zsofia Kote-JaraiDavid E. Neal, Lynne R. Wilkens, Kristine R. Monroe, Daniel O. Stram, Kenneth Muir, Rosalind A. Eeles, Douglas F. Easton, Laurence N. Kolonel, Brian E. Henderson, Loïc Le Marchand, Christopher A. Haiman

Research output: Contribution to journalArticle

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Abstract

Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.

Original languageEnglish
Pages (from-to)2048-2058
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number11
DOIs
Publication statusPublished - 01-11-2012

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Hispanic Americans
Prostatic Neoplasms
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genome
Chromosomes, Human, Pair 6
Genetic Models
Computer Simulation
Alleles

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Cheng, I., Chen, G. K., Nakagawa, H., He, J., Wan, P., Laurie, C. C., ... Haiman, C. A. (2012). Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiology Biomarkers and Prevention, 21(11), 2048-2058. https://doi.org/10.1158/1055-9965.EPI-12-0598
Cheng, Iona ; Chen, Gary K. ; Nakagawa, Hidewaki ; He, Jing ; Wan, Peggy ; Laurie, Cathy C. ; Shen, Jess ; Sheng, Xin ; Pooler, Loreall C. ; Crenshaw, Andrew T. ; Mirel, Daniel B. ; Takahashi, Atsushi ; Kubo, Michiaki ; Nakamura, Yusuke ; Al Olama, Ali Amin ; Benlloch, Sara ; Donovan, Jenny L. ; Guy, Michelle ; Hamdy, Freddie C. ; Kote-Jarai, Zsofia ; Neal, David E. ; Wilkens, Lynne R. ; Monroe, Kristine R. ; Stram, Daniel O. ; Muir, Kenneth ; Eeles, Rosalind A. ; Easton, Douglas F. ; Kolonel, Laurence N. ; Henderson, Brian E. ; Le Marchand, Loïc ; Haiman, Christopher A. / Evaluating genetic risk for prostate cancer among Japanese and Latinos. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 11. pp. 2048-2058.
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abstract = "Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79{\%} and 88{\%}, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.",
author = "Iona Cheng and Chen, {Gary K.} and Hidewaki Nakagawa and Jing He and Peggy Wan and Laurie, {Cathy C.} and Jess Shen and Xin Sheng and Pooler, {Loreall C.} and Crenshaw, {Andrew T.} and Mirel, {Daniel B.} and Atsushi Takahashi and Michiaki Kubo and Yusuke Nakamura and {Al Olama}, {Ali Amin} and Sara Benlloch and Donovan, {Jenny L.} and Michelle Guy and Hamdy, {Freddie C.} and Zsofia Kote-Jarai and Neal, {David E.} and Wilkens, {Lynne R.} and Monroe, {Kristine R.} and Stram, {Daniel O.} and Kenneth Muir and Eeles, {Rosalind A.} and Easton, {Douglas F.} and Kolonel, {Laurence N.} and Henderson, {Brian E.} and {Le Marchand}, Lo{\"i}c and Haiman, {Christopher A.}",
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Cheng, I, Chen, GK, Nakagawa, H, He, J, Wan, P, Laurie, CC, Shen, J, Sheng, X, Pooler, LC, Crenshaw, AT, Mirel, DB, Takahashi, A, Kubo, M, Nakamura, Y, Al Olama, AA, Benlloch, S, Donovan, JL, Guy, M, Hamdy, FC, Kote-Jarai, Z, Neal, DE, Wilkens, LR, Monroe, KR, Stram, DO, Muir, K, Eeles, RA, Easton, DF, Kolonel, LN, Henderson, BE, Le Marchand, L & Haiman, CA 2012, 'Evaluating genetic risk for prostate cancer among Japanese and Latinos', Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 11, pp. 2048-2058. https://doi.org/10.1158/1055-9965.EPI-12-0598

Evaluating genetic risk for prostate cancer among Japanese and Latinos. / Cheng, Iona; Chen, Gary K.; Nakagawa, Hidewaki; He, Jing; Wan, Peggy; Laurie, Cathy C.; Shen, Jess; Sheng, Xin; Pooler, Loreall C.; Crenshaw, Andrew T.; Mirel, Daniel B.; Takahashi, Atsushi; Kubo, Michiaki; Nakamura, Yusuke; Al Olama, Ali Amin; Benlloch, Sara; Donovan, Jenny L.; Guy, Michelle; Hamdy, Freddie C.; Kote-Jarai, Zsofia; Neal, David E.; Wilkens, Lynne R.; Monroe, Kristine R.; Stram, Daniel O.; Muir, Kenneth; Eeles, Rosalind A.; Easton, Douglas F.; Kolonel, Laurence N.; Henderson, Brian E.; Le Marchand, Loïc; Haiman, Christopher A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 11, 01.11.2012, p. 2048-2058.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluating genetic risk for prostate cancer among Japanese and Latinos

AU - Cheng, Iona

AU - Chen, Gary K.

AU - Nakagawa, Hidewaki

AU - He, Jing

AU - Wan, Peggy

AU - Laurie, Cathy C.

AU - Shen, Jess

AU - Sheng, Xin

AU - Pooler, Loreall C.

AU - Crenshaw, Andrew T.

AU - Mirel, Daniel B.

AU - Takahashi, Atsushi

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Donovan, Jenny L.

AU - Guy, Michelle

AU - Hamdy, Freddie C.

AU - Kote-Jarai, Zsofia

AU - Neal, David E.

AU - Wilkens, Lynne R.

AU - Monroe, Kristine R.

AU - Stram, Daniel O.

AU - Muir, Kenneth

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Kolonel, Laurence N.

AU - Henderson, Brian E.

AU - Le Marchand, Loïc

AU - Haiman, Christopher A.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.

AB - Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.

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