TY - JOUR
T1 - Evaluating genetic risk for prostate cancer among Japanese and Latinos
AU - Cheng, Iona
AU - Chen, Gary K.
AU - Nakagawa, Hidewaki
AU - He, Jing
AU - Wan, Peggy
AU - Laurie, Cathy C.
AU - Shen, Jess
AU - Sheng, Xin
AU - Pooler, Loreall C.
AU - Crenshaw, Andrew T.
AU - Mirel, Daniel B.
AU - Takahashi, Atsushi
AU - Kubo, Michiaki
AU - Nakamura, Yusuke
AU - Al Olama, Ali Amin
AU - Benlloch, Sara
AU - Donovan, Jenny L.
AU - Guy, Michelle
AU - Hamdy, Freddie C.
AU - Kote-Jarai, Zsofia
AU - Neal, David E.
AU - Wilkens, Lynne R.
AU - Monroe, Kristine R.
AU - Stram, Daniel O.
AU - Muir, Kenneth
AU - Eeles, Rosalind A.
AU - Easton, Douglas F.
AU - Kolonel, Laurence N.
AU - Henderson, Brian E.
AU - Le Marchand, Loïc
AU - Haiman, Christopher A.
PY - 2012/11
Y1 - 2012/11
N2 - Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.
AB - Background: There have been few genome-wide association studies (GWAS) of prostate cancer among diverse populations. To search for novel prostate cancer risk variants, we conducted GWAS of prostate cancer in Japanese and Latinos. In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos. Methods: Our first-stage GWAS of prostate cancer included Japanese (cases/controls = 1,033/1,042) and Latino (cases/controls = 1,043/1,057) from the Multiethnic Cohort (MEC). Significant associations from stage I (P < 1.0 × 10-4) were examined in silico in GWAS of prostate cancer (stage II) in Japanese (cases/controls = 1,583/3,386) and Europeans (cases/controls = 1,854/1,894). Results: No novel stage I single-nucleotide polymorphism (SNP) outside of known risk regions reached genome-wide significance. For Japanese, in stage I, the most notable putative novel association was seen with 10 SNPs (P ≤ 8.0 × 10-6) at chromosome 2q33; however, this was not replicated in stage II. For Latinos, the most significant association was observed with rs17023900 at the known 3p12 risk locus (stage I:OR = 1.45; P = 7.01 × 10-5 and stage II: OR = 1.58; P = 3.05 × 10-7). The majority of the established risk variants for prostate cancer, 79% and 88%, were positively associated with prostate cancer in Japanese and Latinos (stage I), respectively. The cumulative effects of these variants significantly influence prostate cancer risk (OR per allele = 1.10; P = 2.71 × 10-25 and OR = 1.07; P = 1.02 × 10-16 for Japanese and Latinos, respectively). Conclusion and Impact: Our GWAS of prostate cancer did not identify novel genome-wide significant variants. However, our findings show that established risk variants for prostate cancer significantly contribute to risk among Japanese and Latinos.
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U2 - 10.1158/1055-9965.EPI-12-0598
DO - 10.1158/1055-9965.EPI-12-0598
M3 - Article
C2 - 22923026
AN - SCOPUS:84869211006
SN - 1055-9965
VL - 21
SP - 2048
EP - 2058
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 11
ER -