Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET

Hiroshi Toyama, Masanori Ichise, Jeih San Liow, Douglass C. Vines, Nicholas M. Seneca, Kendra J. Modell, Jurgen Seidel, Michael V. Green, Robert B. Innis

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/ xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalNuclear Medicine and Biology
Issue number2
Publication statusPublished - 02-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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