Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET

Hiroshi Toyama; Masanori Ichise; Jeih San Liow; Douglass C. Vines; Nicholas M. Seneca; Kendra J. Modell; Jurgen Seidel; Michael V. Green; Robert B. Innis

doi:10.1016/S0969-8051(03)00124-0

Evaluation of anesthesia effects on [¹⁸F]FDG uptake in mouse brain and heart using small animal PET

Hiroshi Toyama
, Masanori Ichise
, Jeih San Liow
, Douglass C. Vines
, Nicholas M. Seneca
, Kendra J. Modell
, Jurgen Seidel
, Michael V. Green
, Robert B. Innis

Research output: Contribution to journal › Article › peer-review

143 Citations (Scopus)

Abstract

This study evaluates effects of anesthesia on ¹⁸F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/ xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/S0969-8051(03)00124-0
Publication status	Published - 02-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0969-8051(03)00124-0

Cite this

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title = "Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET",

abstract = "This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (\%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, \%ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/ xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.",

author = "Hiroshi Toyama and Masanori Ichise and Liow, \{Jeih San\} and Vines, \{Douglass C.\} and Seneca, \{Nicholas M.\} and Modell, \{Kendra J.\} and Jurgen Seidel and Green, \{Michael V.\} and Innis, \{Robert B.\}",

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T1 - Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET

AU - Toyama, Hiroshi

AU - Ichise, Masanori

AU - Liow, Jeih San

AU - Vines, Douglass C.

AU - Seneca, Nicholas M.

AU - Modell, Kendra J.

AU - Seidel, Jurgen

AU - Green, Michael V.

AU - Innis, Robert B.

PY - 2004/2

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AB - This study evaluates effects of anesthesia on 18F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/ xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.

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