Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

T. Fujimoto; T. Andoh; T. Sudo; I. Fujita; M. Imabori; H. Moritake; T. Sugimoto; Y. Sakuma; T. Takeuchi; H. Sonobe; Alan L. Epstein; T. Akisue; M. Kirihata; M. Kurosaka; Y. Fukumori; H. Ichikawa

doi:10.1016/j.apradiso.2011.02.006

Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

T. Fujimoto, T. Andoh, T. Sudo, I. Fujita, M. Imabori, H. Moritake, T. Sugimoto, Y. Sakuma, T. Takeuchi, H. Sonobe, Alan L. Epstein, T. Akisue, M. Kirihata, M. Kurosaka, Y. Fukumori, H. Ichikawa

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.

Original language	English
Pages (from-to)	1713-1716
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2011.02.006
Publication status	Published - 12-2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

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Fujimoto, T., Andoh, T., Sudo, T., Fujita, I., Imabori, M., Moritake, H., Sugimoto, T., Sakuma, Y., Takeuchi, T., Sonobe, H., Epstein, A. L., Akisue, T., Kirihata, M., Kurosaka, M., Fukumori, Y., & Ichikawa, H. (2011). Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies. Applied Radiation and Isotopes, 69(12), 1713-1716. https://doi.org/10.1016/j.apradiso.2011.02.006

@article{abe777bee6294dadad6bbb668161900f,

title = "Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies",

abstract = "Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.",

author = "T. Fujimoto and T. Andoh and T. Sudo and I. Fujita and M. Imabori and H. Moritake and T. Sugimoto and Y. Sakuma and T. Takeuchi and H. Sonobe and Epstein, {Alan L.} and T. Akisue and M. Kirihata and M. Kurosaka and Y. Fukumori and H. Ichikawa",

year = "2011",

month = dec,

doi = "10.1016/j.apradiso.2011.02.006",

language = "English",

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journal = "Applied Radiation and Isotopes",

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Fujimoto, T, Andoh, T, Sudo, T, Fujita, I, Imabori, M, Moritake, H, Sugimoto, T, Sakuma, Y, Takeuchi, T, Sonobe, H, Epstein, AL, Akisue, T, Kirihata, M, Kurosaka, M, Fukumori, Y & Ichikawa, H 2011, 'Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies', Applied Radiation and Isotopes, vol. 69, no. 12, pp. 1713-1716. https://doi.org/10.1016/j.apradiso.2011.02.006

TY - JOUR

T1 - Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

AU - Fujimoto, T.

AU - Andoh, T.

AU - Sudo, T.

AU - Fujita, I.

AU - Imabori, M.

AU - Moritake, H.

AU - Sugimoto, T.

AU - Sakuma, Y.

AU - Takeuchi, T.

AU - Sonobe, H.

AU - Epstein, Alan L.

AU - Akisue, T.

AU - Kirihata, M.

AU - Kurosaka, M.

AU - Fukumori, Y.

AU - Ichikawa, H.

PY - 2011/12

Y1 - 2011/12

N2 - Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.

AB - Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.

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DO - 10.1016/j.apradiso.2011.02.006

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AN - SCOPUS:80055074934

SN - 0969-8043

VL - 69

SP - 1713

EP - 1716

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 12

ER -

Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

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