Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT

Hiroshi Toyama, G. Takeshita, A. Takeuchi, K. Ejiri, H. Maeda, K. Kata da, S. Koga, Y. Kato, M. Abe, H. Sano, T. Kanno

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To evaluate cerebral hemodynamics by N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) preoperative and postoperative (after 1 day, and after 7-10 days) regional cerebral blood flow scan, 6 arteriovenous malformations (AVMs) which performed total removal operations were studied by using a ring type SPECT 'HEADTOME'. We performed the dynamic scan just after the intravenous injection of 222 MBq (6 mCi) of 123I-IMP, then the static scan 20 minutes after the intravenous injection. In preoperative dynamic scans of all cases, only the first frame image showed the increased activity on the nidus probably because of the blood pool. Preoperative static scans of all cases showed the remarkable decreased activity on the nidus, and decreased activity surrounding the nidus probably because of the peripheral steal phenomenon. In postoperative scan of the next day, 4 out of 6 cases showed the transient decreased peripheral steal, particularly 2 out of those 4 cases showed the transient hyperperfusion probably because of the normal perfusion pressure breakthrough (NPPB). And, 2 out of 6 cases showed transient peripheral low perfusion on much larger area than those of the preoperative scans probably because of the focal brain damages and edemas. We conclude that 123I-IMP SPECT on AVM is very usuful to decide the indication of the removal operation, and to estimate the postoperative risk, and to evaluate the preoperative and postoperative cerebral hemodynamic changes in the peripheral area of AVM.

Original languageEnglish
Pages (from-to)1479-1486
Number of pages8
JournalKakuigaku
Volume26
Issue number12
Publication statusPublished - 01-12-1989

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Iofetamine
Intracranial Arteriovenous Malformations
Arteriovenous Malformations
Single-Photon Emission-Computed Tomography
Hemodynamics
Intravenous Injections
Cerebrovascular Circulation
Perfusion
Brain Edema
Regional Blood Flow
Pressure

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Toyama, H., Takeshita, G., Takeuchi, A., Ejiri, K., Maeda, H., Kata da, K., ... Kanno, T. (1989). Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT. Kakuigaku, 26(12), 1479-1486.
Toyama, Hiroshi ; Takeshita, G. ; Takeuchi, A. ; Ejiri, K. ; Maeda, H. ; Kata da, K. ; Koga, S. ; Kato, Y. ; Abe, M. ; Sano, H. ; Kanno, T. / Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT. In: Kakuigaku. 1989 ; Vol. 26, No. 12. pp. 1479-1486.
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abstract = "To evaluate cerebral hemodynamics by N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) preoperative and postoperative (after 1 day, and after 7-10 days) regional cerebral blood flow scan, 6 arteriovenous malformations (AVMs) which performed total removal operations were studied by using a ring type SPECT 'HEADTOME'. We performed the dynamic scan just after the intravenous injection of 222 MBq (6 mCi) of 123I-IMP, then the static scan 20 minutes after the intravenous injection. In preoperative dynamic scans of all cases, only the first frame image showed the increased activity on the nidus probably because of the blood pool. Preoperative static scans of all cases showed the remarkable decreased activity on the nidus, and decreased activity surrounding the nidus probably because of the peripheral steal phenomenon. In postoperative scan of the next day, 4 out of 6 cases showed the transient decreased peripheral steal, particularly 2 out of those 4 cases showed the transient hyperperfusion probably because of the normal perfusion pressure breakthrough (NPPB). And, 2 out of 6 cases showed transient peripheral low perfusion on much larger area than those of the preoperative scans probably because of the focal brain damages and edemas. We conclude that 123I-IMP SPECT on AVM is very usuful to decide the indication of the removal operation, and to estimate the postoperative risk, and to evaluate the preoperative and postoperative cerebral hemodynamic changes in the peripheral area of AVM.",
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Toyama, H, Takeshita, G, Takeuchi, A, Ejiri, K, Maeda, H, Kata da, K, Koga, S, Kato, Y, Abe, M, Sano, H & Kanno, T 1989, 'Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT', Kakuigaku, vol. 26, no. 12, pp. 1479-1486.

Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT. / Toyama, Hiroshi; Takeshita, G.; Takeuchi, A.; Ejiri, K.; Maeda, H.; Kata da, K.; Koga, S.; Kato, Y.; Abe, M.; Sano, H.; Kanno, T.

In: Kakuigaku, Vol. 26, No. 12, 01.12.1989, p. 1479-1486.

Research output: Contribution to journalArticle

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T1 - Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT

AU - Toyama, Hiroshi

AU - Takeshita, G.

AU - Takeuchi, A.

AU - Ejiri, K.

AU - Maeda, H.

AU - Kata da, K.

AU - Koga, S.

AU - Kato, Y.

AU - Abe, M.

AU - Sano, H.

AU - Kanno, T.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - To evaluate cerebral hemodynamics by N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) preoperative and postoperative (after 1 day, and after 7-10 days) regional cerebral blood flow scan, 6 arteriovenous malformations (AVMs) which performed total removal operations were studied by using a ring type SPECT 'HEADTOME'. We performed the dynamic scan just after the intravenous injection of 222 MBq (6 mCi) of 123I-IMP, then the static scan 20 minutes after the intravenous injection. In preoperative dynamic scans of all cases, only the first frame image showed the increased activity on the nidus probably because of the blood pool. Preoperative static scans of all cases showed the remarkable decreased activity on the nidus, and decreased activity surrounding the nidus probably because of the peripheral steal phenomenon. In postoperative scan of the next day, 4 out of 6 cases showed the transient decreased peripheral steal, particularly 2 out of those 4 cases showed the transient hyperperfusion probably because of the normal perfusion pressure breakthrough (NPPB). And, 2 out of 6 cases showed transient peripheral low perfusion on much larger area than those of the preoperative scans probably because of the focal brain damages and edemas. We conclude that 123I-IMP SPECT on AVM is very usuful to decide the indication of the removal operation, and to estimate the postoperative risk, and to evaluate the preoperative and postoperative cerebral hemodynamic changes in the peripheral area of AVM.

AB - To evaluate cerebral hemodynamics by N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) preoperative and postoperative (after 1 day, and after 7-10 days) regional cerebral blood flow scan, 6 arteriovenous malformations (AVMs) which performed total removal operations were studied by using a ring type SPECT 'HEADTOME'. We performed the dynamic scan just after the intravenous injection of 222 MBq (6 mCi) of 123I-IMP, then the static scan 20 minutes after the intravenous injection. In preoperative dynamic scans of all cases, only the first frame image showed the increased activity on the nidus probably because of the blood pool. Preoperative static scans of all cases showed the remarkable decreased activity on the nidus, and decreased activity surrounding the nidus probably because of the peripheral steal phenomenon. In postoperative scan of the next day, 4 out of 6 cases showed the transient decreased peripheral steal, particularly 2 out of those 4 cases showed the transient hyperperfusion probably because of the normal perfusion pressure breakthrough (NPPB). And, 2 out of 6 cases showed transient peripheral low perfusion on much larger area than those of the preoperative scans probably because of the focal brain damages and edemas. We conclude that 123I-IMP SPECT on AVM is very usuful to decide the indication of the removal operation, and to estimate the postoperative risk, and to evaluate the preoperative and postoperative cerebral hemodynamic changes in the peripheral area of AVM.

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Toyama H, Takeshita G, Takeuchi A, Ejiri K, Maeda H, Kata da K et al. Evaluation of cerebral hemodynamics by 123I-IMP in cerebral AVMs before and after operation by using SPECT. Kakuigaku. 1989 Dec 1;26(12):1479-1486.