Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.

Kazumitsu Sugiura, Satoko Hirai, Tamio Suzuki, Toshikazu Usuda, Takao Kondo, Teruo Azumi, Sadao Masaki, Takaomi Yokoi, Yukiko Nitta, Shigeri Kamiya, Koichi Ando, Takako Mori, Yasushi Tomita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria. A secondary aim was to identify the optimal alternative treatments when switching from this drug to other drugs in patients who are dissatisfied with cetirizine. We started cetirizine at a once-daily dose of 10 mg for 2 weeks and then, depending on the course of symptoms in individual patients, it was either continued, titrated to a higher dose, or switched to other drugs (antihistamines including H2 blockers) for a further 2 weeks. Degrees of patient satisfaction and ratings by physicians were analyzed, as were adverse events. At 2 weeks after the start of treatment, among 74 patients included in the final evaluation 55 (74.3%) expressed satisfaction with cetirizine therapy. Those not satisfied included five (6.7%) who felt drowsy after taking the drug and 14 (18.9%) in whom the drug had not demonstrated adequate efficacy. After optimizing the treatment on a per-patient basis, including switching from cetirizine to other drugs, the percentage satisfied with treatment at 4 weeks was 83.7% (62/74). In the group of patients who were satisfied with the therapy at 2 weeks, attending physicians confirmed that wheals and scratches were significantly alleviated at 2 and 4 weeks, respectively. Adverse effects were mild and uncommon. Cetirizine as an initial treatment for chronic urticaria appears effective and safe. For patients in whom cetirizine fails to satisfactorily alleviate symptoms as well as those who complain of drowsiness, switching to other antihistamine drugs may be an effective strategy.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalNagoya journal of medical science
Volume70
Issue number3-4
Publication statusPublished - 01-01-2008
Externally publishedYes

Fingerprint

Cetirizine
Urticaria
Pharmaceutical Preparations
Histamine Antagonists
Therapeutics
Drug Substitution
Physicians
Sleep Stages
Patient Satisfaction

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sugiura, K., Hirai, S., Suzuki, T., Usuda, T., Kondo, T., Azumi, T., ... Tomita, Y. (2008). Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. Nagoya journal of medical science, 70(3-4), 97-106.
Sugiura, Kazumitsu ; Hirai, Satoko ; Suzuki, Tamio ; Usuda, Toshikazu ; Kondo, Takao ; Azumi, Teruo ; Masaki, Sadao ; Yokoi, Takaomi ; Nitta, Yukiko ; Kamiya, Shigeri ; Ando, Koichi ; Mori, Takako ; Tomita, Yasushi. / Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. In: Nagoya journal of medical science. 2008 ; Vol. 70, No. 3-4. pp. 97-106.
@article{38cd03103d10441d904b8bee5d01cdcb,
title = "Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.",
abstract = "We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria. A secondary aim was to identify the optimal alternative treatments when switching from this drug to other drugs in patients who are dissatisfied with cetirizine. We started cetirizine at a once-daily dose of 10 mg for 2 weeks and then, depending on the course of symptoms in individual patients, it was either continued, titrated to a higher dose, or switched to other drugs (antihistamines including H2 blockers) for a further 2 weeks. Degrees of patient satisfaction and ratings by physicians were analyzed, as were adverse events. At 2 weeks after the start of treatment, among 74 patients included in the final evaluation 55 (74.3{\%}) expressed satisfaction with cetirizine therapy. Those not satisfied included five (6.7{\%}) who felt drowsy after taking the drug and 14 (18.9{\%}) in whom the drug had not demonstrated adequate efficacy. After optimizing the treatment on a per-patient basis, including switching from cetirizine to other drugs, the percentage satisfied with treatment at 4 weeks was 83.7{\%} (62/74). In the group of patients who were satisfied with the therapy at 2 weeks, attending physicians confirmed that wheals and scratches were significantly alleviated at 2 and 4 weeks, respectively. Adverse effects were mild and uncommon. Cetirizine as an initial treatment for chronic urticaria appears effective and safe. For patients in whom cetirizine fails to satisfactorily alleviate symptoms as well as those who complain of drowsiness, switching to other antihistamine drugs may be an effective strategy.",
author = "Kazumitsu Sugiura and Satoko Hirai and Tamio Suzuki and Toshikazu Usuda and Takao Kondo and Teruo Azumi and Sadao Masaki and Takaomi Yokoi and Yukiko Nitta and Shigeri Kamiya and Koichi Ando and Takako Mori and Yasushi Tomita",
year = "2008",
month = "1",
day = "1",
language = "English",
volume = "70",
pages = "97--106",
journal = "Nagoya Journal of Medical Science",
issn = "0027-7622",
publisher = "Nagoya University, School of Medicine",
number = "3-4",

}

Sugiura, K, Hirai, S, Suzuki, T, Usuda, T, Kondo, T, Azumi, T, Masaki, S, Yokoi, T, Nitta, Y, Kamiya, S, Ando, K, Mori, T & Tomita, Y 2008, 'Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.', Nagoya journal of medical science, vol. 70, no. 3-4, pp. 97-106.

Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. / Sugiura, Kazumitsu; Hirai, Satoko; Suzuki, Tamio; Usuda, Toshikazu; Kondo, Takao; Azumi, Teruo; Masaki, Sadao; Yokoi, Takaomi; Nitta, Yukiko; Kamiya, Shigeri; Ando, Koichi; Mori, Takako; Tomita, Yasushi.

In: Nagoya journal of medical science, Vol. 70, No. 3-4, 01.01.2008, p. 97-106.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.

AU - Sugiura, Kazumitsu

AU - Hirai, Satoko

AU - Suzuki, Tamio

AU - Usuda, Toshikazu

AU - Kondo, Takao

AU - Azumi, Teruo

AU - Masaki, Sadao

AU - Yokoi, Takaomi

AU - Nitta, Yukiko

AU - Kamiya, Shigeri

AU - Ando, Koichi

AU - Mori, Takako

AU - Tomita, Yasushi

PY - 2008/1/1

Y1 - 2008/1/1

N2 - We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria. A secondary aim was to identify the optimal alternative treatments when switching from this drug to other drugs in patients who are dissatisfied with cetirizine. We started cetirizine at a once-daily dose of 10 mg for 2 weeks and then, depending on the course of symptoms in individual patients, it was either continued, titrated to a higher dose, or switched to other drugs (antihistamines including H2 blockers) for a further 2 weeks. Degrees of patient satisfaction and ratings by physicians were analyzed, as were adverse events. At 2 weeks after the start of treatment, among 74 patients included in the final evaluation 55 (74.3%) expressed satisfaction with cetirizine therapy. Those not satisfied included five (6.7%) who felt drowsy after taking the drug and 14 (18.9%) in whom the drug had not demonstrated adequate efficacy. After optimizing the treatment on a per-patient basis, including switching from cetirizine to other drugs, the percentage satisfied with treatment at 4 weeks was 83.7% (62/74). In the group of patients who were satisfied with the therapy at 2 weeks, attending physicians confirmed that wheals and scratches were significantly alleviated at 2 and 4 weeks, respectively. Adverse effects were mild and uncommon. Cetirizine as an initial treatment for chronic urticaria appears effective and safe. For patients in whom cetirizine fails to satisfactorily alleviate symptoms as well as those who complain of drowsiness, switching to other antihistamine drugs may be an effective strategy.

AB - We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria. A secondary aim was to identify the optimal alternative treatments when switching from this drug to other drugs in patients who are dissatisfied with cetirizine. We started cetirizine at a once-daily dose of 10 mg for 2 weeks and then, depending on the course of symptoms in individual patients, it was either continued, titrated to a higher dose, or switched to other drugs (antihistamines including H2 blockers) for a further 2 weeks. Degrees of patient satisfaction and ratings by physicians were analyzed, as were adverse events. At 2 weeks after the start of treatment, among 74 patients included in the final evaluation 55 (74.3%) expressed satisfaction with cetirizine therapy. Those not satisfied included five (6.7%) who felt drowsy after taking the drug and 14 (18.9%) in whom the drug had not demonstrated adequate efficacy. After optimizing the treatment on a per-patient basis, including switching from cetirizine to other drugs, the percentage satisfied with treatment at 4 weeks was 83.7% (62/74). In the group of patients who were satisfied with the therapy at 2 weeks, attending physicians confirmed that wheals and scratches were significantly alleviated at 2 and 4 weeks, respectively. Adverse effects were mild and uncommon. Cetirizine as an initial treatment for chronic urticaria appears effective and safe. For patients in whom cetirizine fails to satisfactorily alleviate symptoms as well as those who complain of drowsiness, switching to other antihistamine drugs may be an effective strategy.

UR - http://www.scopus.com/inward/record.url?scp=58149145685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149145685&partnerID=8YFLogxK

M3 - Article

VL - 70

SP - 97

EP - 106

JO - Nagoya Journal of Medical Science

JF - Nagoya Journal of Medical Science

SN - 0027-7622

IS - 3-4

ER -