Evaluation of chemotherapy for gastric cancer by endoscopic ultrasonography

Hiroshi Nishio, Saburo Nakazawa, Junji Yoshino, Kazuo Inui, Takao Wakabayashi, Kazumu Okushima, Takashi Kobayashi, Yuta Nakamura, Ryuichi Kato, Shinya Watanabe

Research output: Contribution to journalArticlepeer-review

Abstract

We judged the efficacy of chemotherapy using endoscopic ultrasonography (EUS) in 26 cases of gastric cancer. Treatment efficacy was evaluated according to the General Rules for the Gastric Cancer Study, based on the reduction of the largest cross-sectional area of the tumor. A reduction of over 50% was rated as U-PR and a reduction of -25-50% was rated as U-NC. Our findings showed U-PR in 11 cases and U-NC in 15 cases. Three cases initially considered to be NC according to the rules were judged to be U-PR based on EUS findings. Marked therapeutic in these 3 cases was demonstrated clinically and this was confirmed by EUS findings. Generalized Wilcoxon test showed a significant difference in the cumulative survival rate between U-PR and U-NC cases (p<0.05). EUS provides an objective means of evaluating the efficacy of chemotherapy in gastric cancer patients, including those with lesions that cannot be evaluated by the General Rules for Gastric Cancer Study.

Original languageEnglish
Pages (from-to)416-425
Number of pages10
JournalJapanese Journal of Gastroenterology
Volume97
Issue number4
Publication statusPublished - 01-04-2000

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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