Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows

Tursun Alkam, Hyoung Chun Kim, Masayuki Hiramatsu, Takayoshi Mamiya, Yuki Aoyama, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Nicotine replacement treatments are being alternatively applied as an aid to smoking cessation during pregnancy. However, the effects of nicotine exposed at the prenatal stage on the emotional behaviors in offspring are not well understood due to the lack of systematic investigations. The current study has therefore initially aimed to evaluate emotional behaviors in young mouse offspring (postnatal day 28-36) which experienced gestational and/or perinatal nicotine exposure (GPNE) in six different time-windows. Pregnant C57BL/6J mice were exposed to nicotine via sweetened (2% sucrose) drinking water during 6 different time-windows including gestational day 0-day 13 (G0-G13), G14-perinatal day 0 (P0), G0-P0, G14-P7, G0-P7, and P0-P7. During P28-P36 days, both male and female offspring were given a battery of behavioral tests including light and dark box test, marble burying behavior test, novelty-suppressed feeding test, sociability and social novelty preference test, social avoidance tube test, and elevated plus maze test. GPNE during G0-P0, G14-P0, G14-P7, and G0-P7 induced abnormal behaviors in male and female offspring to different extent. Results indicated that nicotine at any time points of gestational and/or perinatal period impairs emotional behaviors in offspring, and suggested certain time-windows for further neurochemical or molecular studies in relation with GPNE-induced emotional abnormalities.

Original languageEnglish
Pages (from-to)80-89
Number of pages10
JournalBehavioural Brain Research
Volume239
Issue number1
DOIs
Publication statusPublished - 15-02-2013
Externally publishedYes

Fingerprint

Nicotine
Inbred C57BL Mouse
Calcium Carbonate
Smoking Cessation
Drinking Water
Sucrose
Light
Pregnancy

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Alkam, Tursun ; Kim, Hyoung Chun ; Hiramatsu, Masayuki ; Mamiya, Takayoshi ; Aoyama, Yuki ; Nitta, Atsumi ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. In: Behavioural Brain Research. 2013 ; Vol. 239, No. 1. pp. 80-89.
@article{c7f9ee34d77b45c49277b5929d3b9029,
title = "Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows",
abstract = "Nicotine replacement treatments are being alternatively applied as an aid to smoking cessation during pregnancy. However, the effects of nicotine exposed at the prenatal stage on the emotional behaviors in offspring are not well understood due to the lack of systematic investigations. The current study has therefore initially aimed to evaluate emotional behaviors in young mouse offspring (postnatal day 28-36) which experienced gestational and/or perinatal nicotine exposure (GPNE) in six different time-windows. Pregnant C57BL/6J mice were exposed to nicotine via sweetened (2{\%} sucrose) drinking water during 6 different time-windows including gestational day 0-day 13 (G0-G13), G14-perinatal day 0 (P0), G0-P0, G14-P7, G0-P7, and P0-P7. During P28-P36 days, both male and female offspring were given a battery of behavioral tests including light and dark box test, marble burying behavior test, novelty-suppressed feeding test, sociability and social novelty preference test, social avoidance tube test, and elevated plus maze test. GPNE during G0-P0, G14-P0, G14-P7, and G0-P7 induced abnormal behaviors in male and female offspring to different extent. Results indicated that nicotine at any time points of gestational and/or perinatal period impairs emotional behaviors in offspring, and suggested certain time-windows for further neurochemical or molecular studies in relation with GPNE-induced emotional abnormalities.",
author = "Tursun Alkam and Kim, {Hyoung Chun} and Masayuki Hiramatsu and Takayoshi Mamiya and Yuki Aoyama and Atsumi Nitta and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2013",
month = "2",
day = "15",
doi = "10.1016/j.bbr.2012.10.058",
language = "English",
volume = "239",
pages = "80--89",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. / Alkam, Tursun; Kim, Hyoung Chun; Hiramatsu, Masayuki; Mamiya, Takayoshi; Aoyama, Yuki; Nitta, Atsumi; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 239, No. 1, 15.02.2013, p. 80-89.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows

AU - Alkam, Tursun

AU - Kim, Hyoung Chun

AU - Hiramatsu, Masayuki

AU - Mamiya, Takayoshi

AU - Aoyama, Yuki

AU - Nitta, Atsumi

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Nicotine replacement treatments are being alternatively applied as an aid to smoking cessation during pregnancy. However, the effects of nicotine exposed at the prenatal stage on the emotional behaviors in offspring are not well understood due to the lack of systematic investigations. The current study has therefore initially aimed to evaluate emotional behaviors in young mouse offspring (postnatal day 28-36) which experienced gestational and/or perinatal nicotine exposure (GPNE) in six different time-windows. Pregnant C57BL/6J mice were exposed to nicotine via sweetened (2% sucrose) drinking water during 6 different time-windows including gestational day 0-day 13 (G0-G13), G14-perinatal day 0 (P0), G0-P0, G14-P7, G0-P7, and P0-P7. During P28-P36 days, both male and female offspring were given a battery of behavioral tests including light and dark box test, marble burying behavior test, novelty-suppressed feeding test, sociability and social novelty preference test, social avoidance tube test, and elevated plus maze test. GPNE during G0-P0, G14-P0, G14-P7, and G0-P7 induced abnormal behaviors in male and female offspring to different extent. Results indicated that nicotine at any time points of gestational and/or perinatal period impairs emotional behaviors in offspring, and suggested certain time-windows for further neurochemical or molecular studies in relation with GPNE-induced emotional abnormalities.

AB - Nicotine replacement treatments are being alternatively applied as an aid to smoking cessation during pregnancy. However, the effects of nicotine exposed at the prenatal stage on the emotional behaviors in offspring are not well understood due to the lack of systematic investigations. The current study has therefore initially aimed to evaluate emotional behaviors in young mouse offspring (postnatal day 28-36) which experienced gestational and/or perinatal nicotine exposure (GPNE) in six different time-windows. Pregnant C57BL/6J mice were exposed to nicotine via sweetened (2% sucrose) drinking water during 6 different time-windows including gestational day 0-day 13 (G0-G13), G14-perinatal day 0 (P0), G0-P0, G14-P7, G0-P7, and P0-P7. During P28-P36 days, both male and female offspring were given a battery of behavioral tests including light and dark box test, marble burying behavior test, novelty-suppressed feeding test, sociability and social novelty preference test, social avoidance tube test, and elevated plus maze test. GPNE during G0-P0, G14-P0, G14-P7, and G0-P7 induced abnormal behaviors in male and female offspring to different extent. Results indicated that nicotine at any time points of gestational and/or perinatal period impairs emotional behaviors in offspring, and suggested certain time-windows for further neurochemical or molecular studies in relation with GPNE-induced emotional abnormalities.

UR - http://www.scopus.com/inward/record.url?scp=84869864341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869864341&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2012.10.058

DO - 10.1016/j.bbr.2012.10.058

M3 - Article

VL - 239

SP - 80

EP - 89

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -