Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model

Haruka Nakagawa Kamura; Tetsuo Yamaguchi; Toshihiro Kasama; Yukitaka Hayashi; Masakaze Hamada; Kazuaki Matsumoto; Ryo Miyake; Yoshikazu Ishii

doi:10.1038/s41429-025-00826-7

Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model

Haruka Nakagawa Kamura
, Tetsuo Yamaguchi
, Toshihiro Kasama
, Yukitaka Hayashi
, Masakaze Hamada
, Kazuaki Matsumoto
, Ryo Miyake
, Yoshikazu Ishii

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX’s elevated concentration in ELF plays a significant role in its bactericidal activity.

Original language	English
Article number	e02208–18
Pages (from-to)	388-391
Number of pages	4
Journal	Journal of Antibiotics
Volume	78
Issue number	6
DOIs	https://doi.org/10.1038/s41429-025-00826-7
Publication status	Published - 05-2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1038/s41429-025-00826-7

Cite this

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title = "Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model",

abstract = "Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX{\textquoteright}s elevated concentration in ELF plays a significant role in its bactericidal activity.",

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AU - Kamura, Haruka Nakagawa

AU - Yamaguchi, Tetsuo

AU - Kasama, Toshihiro

AU - Hayashi, Yukitaka

AU - Hamada, Masakaze

AU - Matsumoto, Kazuaki

AU - Miyake, Ryo

AU - Ishii, Yoshikazu

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/5

Y1 - 2025/5

N2 - Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX’s elevated concentration in ELF plays a significant role in its bactericidal activity.

AB - Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX’s elevated concentration in ELF plays a significant role in its bactericidal activity.

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IS - 6

M1 - e02208–18

ER -

Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model

Abstract

All Science Journal Classification (ASJC) codes

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