Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

Jun Kunizaki; Shiro Sugiura; Akira Sakai; Miyuki Teshigawara; Atsushi Makino; Yoshihiro Takasato; Teruaki Matsui; Yasuto Kondo; Komei Ito

doi:10.3389/falgy.2023.1298137

Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

Jun Kunizaki, Shiro Sugiura, Akira Sakai, Miyuki Teshigawara, Atsushi Makino, Yoshihiro Takasato, Teruaki Matsui, Yasuto Kondo, Komei Ito

Pediatrics & Allergy Center

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, in vivo basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.

Original language	English
Article number	1298137
Journal	Frontiers in Allergy
Volume	4
DOIs	https://doi.org/10.3389/falgy.2023.1298137
Publication status	Published - 2023

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/falgy.2023.1298137

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title = "Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients",

abstract = "Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, in vivo basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.",

author = "Jun Kunizaki and Shiro Sugiura and Akira Sakai and Miyuki Teshigawara and Atsushi Makino and Yoshihiro Takasato and Teruaki Matsui and Yasuto Kondo and Komei Ito",

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T1 - Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

AU - Kunizaki, Jun

AU - Sugiura, Shiro

AU - Sakai, Akira

AU - Teshigawara, Miyuki

AU - Makino, Atsushi

AU - Takasato, Yoshihiro

AU - Matsui, Teruaki

AU - Kondo, Yasuto

AU - Ito, Komei

N1 - Publisher Copyright: 2023 Kunizaki, Sugiura, Sakai, Teshigawara, Makino, Takasato, Matsui, Kondo and Ito.

PY - 2023

Y1 - 2023

N2 - Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, in vivo basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.

AB - Some food allergic patients who have undergone oral immunotherapy develop exercise-induced allergic reactions on desensitization (EIARDs). This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD. EPT was performed on 20 participants, and in vivo basophil activation status was analyzed using activation markers CD203c and CD63. The results showed that there was no significant difference between EPT-positive and negative subjects for basophil activation status throughout EPT. Consequently, in vivo basophil activation after ingestion of the causative food may not be associated with EIARDs. New tests are desired for predicting EIARDs.

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Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

Abstract

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