Evaluation of short-term outcomes of intravitreal aflibercept injections for age-related macular degeneration using focal macular electroretinography

Kei Takayama, Hiroki Kaneko, Shinji Ueno, Ruka Maruko, Chang Hua Piao, Shunsuke Yasuda, Kenichi Kawano, Yasuki Ito, Hiroko Terasaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Purpose: To evaluate the relationship between morphological changes and functional improvements assessed using focal macular electroretinograms after intravitreal aflibercept (IVA) injections in eyes with wet age-related macular degeneration. Methods: The clinical records of 42 eyes of 42 consecutive patients with naive, wet agerelated macular degeneration received 3 monthly IVA were reviewed. The best-corrected visual acuity, central foveal thickness, outer retinal thickness, inner retinal thickness at baseline and 1 month after each IVA, and focal macular electroretinograms at baseline and 1 month after the first and third IVA were compared. Results: Best-corrected visual acuity was improved after the third IVA (P = 0.0091). Central foveal thickness and outer retinal thickness showed decreases after every IVA (P < 0.001, respectively). Inner retinal thickness showed a decrease after the second IVA (P = 0.002), after and third IVA (P = 0.001). On focal macular electroretinograms, a-and b-wave amplitudes showed increases after the third IVA (P = 0.0028, P = 0.0012, respectively). Significant correlations were observed between best-corrected visual acuity and central foveal thickness, a-wave amplitude and outer retinal thickness, and b-wave amplitude and inner retinal thickness changes after the third IVA. Conclusion: All parameters significantly recovered after three monthly IVA, with a correlation between functional improvements and morphological changes.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalRetina
Volume37
Issue number3
DOIs
Publication statusPublished - 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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