Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection

Jun Ichi Kawada; Hiroshi Kimura; Yoshinori Ito; Yoshiniro Ando; Naoko Tanaka-Kitajima; Masahiro Hayakawa; Hiroyuki Nunoi; Fumio Endo; Tsuneo Morishima

doi:10.1086/422325

Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection

Jun Ichi Kawada, Hiroshi Kimura, Yoshinori Ito, Yoshiniro Ando, Naoko Tanaka-Kitajima, Masahiro Hayakawa, Hiroyuki Nunoi, Fumio Endo, Tsuneo Morishima

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.

Original language	English
Pages (from-to)	494-498
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	190
Issue number	3
DOIs	https://doi.org/10.1086/422325
Publication status	Published - 01-08-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1086/422325

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author = "Kawada, {Jun Ichi} and Hiroshi Kimura and Yoshinori Ito and Yoshiniro Ando and Naoko Tanaka-Kitajima and Masahiro Hayakawa and Hiroyuki Nunoi and Fumio Endo and Tsuneo Morishima",

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AU - Kawada, Jun Ichi

AU - Kimura, Hiroshi

AU - Ito, Yoshinori

AU - Ando, Yoshiniro

AU - Tanaka-Kitajima, Naoko

AU - Hayakawa, Masahiro

AU - Nunoi, Hiroyuki

AU - Endo, Fumio

AU - Morishima, Tsuneo

PY - 2004/8/1

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N2 - Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.

AB - Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.

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JO - Journal of Infectious Diseases

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Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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