Evaluation of taste of edoxaban ODTs (Orally disintegrating tablets) using a taste sensor and human sensory

Keiko Yamamura, Takashi Osada, Sakiko Nishikawa, Yutaka Kobayashi, Noriaki Hatakeyama, Mayu Shiotani, Eiko Matsuno, Kuniaki Saito

Research output: Contribution to journalArticlepeer-review


Background: The bitter taste of ODTs (orally disintegrating tablet) may occasionally reduce medication adherence, therefore it is important to evaluate the taste of ODT. Purpose:The purpose of this study was to evaluate quantitative bitterness of Edoxaban ODTs using a taste sensor (TS-5000Z). Moreover, we investigated the human sensory evaluation on Edoxaban ODTs medication patients. We collected their medicine instruction records in hospital and pharmacy and investigated them retrospectively. Methods: The first taste and aftertaste of Edoxaban ODTs was measured by seven sensors (bitterness, acid bitterness, saltiness, sourness, umani, astringency, basic bitterness). Results and Conclusion: A taste radar chart of various tastes was made by using SA402B analysis application. An acid bitterness sensor which evaluate the bitterness of pharmaceutical products did not react It was supposed that bitterness after taking edoxaban ODTs was almost not felt. By human sensory evaluation, 185 of 206 (89.8%) patients replied,"It is easy to take edoxaban ODTs", and 193 (93.7%) patients replied,"I don't mind the taste". Not any patient appealed the bitterness. These results indicated that the taste of edxaban ODT did not affect medication adherence. As for the taste quantitative evaluation by TS-5000Z, we suggest it is a useful information to express complicated taste in a visually understandable state.

Original languageEnglish
Pages (from-to)499-508
Number of pages10
JournalTherapeutic Research
Issue number6
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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