Evaluation of the clinical cutoff level of serum (1 → 3)-β-d-glucan in patients with connective tissue diseases complicated by deep fungal infections

Kenichi Kato, Satoru Onoda, Junichiro Asano, Shusaku Fukaya, Shunji Yoshida

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Serum (1 → 3)-β-D-glucan levels and clinical findings were evaluated in 229 inpatients with connective tissue diseases (CTDs) during the period between June and October 2004. The mean serum (1 → 3)-β-D-glucan level was 129.7 ± 207.6 pg/mL in patients with a definitive diagnosis of fungal infections and 10.5 ± 8.6 pg/mL in patients without fungal infections. Analysis of the diagnostic sensitivity/specificity for various (1 → 3)-β-D-glucan cutoff levels gave the best results for a cutoff level of 15 pg/mL, with a sensitivity of 92.3% and specificity of 81.3%. This level was therefore determined to be the optimal cutoff in patients with CTDs.

Original languageEnglish
Pages (from-to)366-369
Number of pages4
JournalModern Rheumatology
Volume20
Issue number4
DOIs
Publication statusPublished - 08-01-2010

All Science Journal Classification (ASJC) codes

  • Rheumatology

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