Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area

Hiroshi Toyama, Gen Takeshita, Kaori Shibata, Masayo Nomura, Toshiteru Fujiwara, Emiko Ishikawa, Michiaki Fujiwara, Naoko Fujii, Kazutaka Ejiri, Hisato Maeda, Kazuhiro Katada, Akira Takeuchi, Sukehiko Koga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to assess the clinical usefulness of super dynamic SPECT of 99mTc-HM-PAO. Six patients with unilateral occlusion of middle cerebral artery (MCA) or internal carotid artery (ICA) in the chronic phase, and 5 patients with subacute cerebral infarction were studied. We used a ring-type SPECT "HEADTOME." Two types of collimator were used: a high sensitivity (HS) collimator for super dynamic scan and a high resolution (HR) collimator for static scan. First, the intravenous constant infusion of 99mTc-HM-PAO (925-1480 MBq) for 1 minute was started. After 30 seconds from the beginning of the injection, we performed the 12 seconds/frame super dynamic SPECT for 2 minutes. Then, the static SPECT for 10 minutes was done. For semiquantitative analyses, differential percentage of regional activity between affected and non-affected hemispheres was calculated in the 6th frame image of super dynamic SPECT and static SPECT image. In all 6 patients with unilateral occlusion of MCA and ICA, super dynamic SPECT images showed the better contrast of low perfusion areas in comparison with the static SPECT images. In 5 patients with subacute cerebral infarction who showed focal hyperactivities on static SPECT, focal hyperactivities (hyperperfusion or hyperemia) were displayed in 3 cases, whereas, focal hypo- or isoactivities (hypo- or isoperfusion) were shown in 2 cases on super dynamic SPECT. However, all patients with subacute cerebral infarction showed hyperfixation on static SPECT as compared with super dynamic SPECT. Although the image quality on super dynamic SPECT is not as high as that on static SPECT, cerebral hemodynamics would be detected with less backdiffusion of 99mTc-HM-PAO from the brain to blood, and with less accumulation of hydrophilic components in subacute infarct region. In conclusion, super dynamic SPECT in early distribution of 99mTc-HM-PAO using dedicated SPECT device might be helpful to detect cerebral perfusion close to true cerebral blood flow distribution.

Original languageEnglish
Pages (from-to)521-529
Number of pages9
JournalKakuigaku
Volume33
Issue number5
Publication statusPublished - 01-12-1996

Fingerprint

Cerebrovascular Disorders
Single-Photon Emission-Computed Tomography
Cerebral Infarction
Middle Cerebral Artery Infarction
Internal Carotid Artery
Cerebrovascular Circulation
Perfusion
Hyperemia

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Toyama, Hiroshi ; Takeshita, Gen ; Shibata, Kaori ; Nomura, Masayo ; Fujiwara, Toshiteru ; Ishikawa, Emiko ; Fujiwara, Michiaki ; Fujii, Naoko ; Ejiri, Kazutaka ; Maeda, Hisato ; Katada, Kazuhiro ; Takeuchi, Akira ; Koga, Sukehiko. / Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area. In: Kakuigaku. 1996 ; Vol. 33, No. 5. pp. 521-529.
@article{069861b393bd4e7c979f8abe9edc50a7,
title = "Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area",
abstract = "The purpose of this study is to assess the clinical usefulness of super dynamic SPECT of 99mTc-HM-PAO. Six patients with unilateral occlusion of middle cerebral artery (MCA) or internal carotid artery (ICA) in the chronic phase, and 5 patients with subacute cerebral infarction were studied. We used a ring-type SPECT {"}HEADTOME.{"} Two types of collimator were used: a high sensitivity (HS) collimator for super dynamic scan and a high resolution (HR) collimator for static scan. First, the intravenous constant infusion of 99mTc-HM-PAO (925-1480 MBq) for 1 minute was started. After 30 seconds from the beginning of the injection, we performed the 12 seconds/frame super dynamic SPECT for 2 minutes. Then, the static SPECT for 10 minutes was done. For semiquantitative analyses, differential percentage of regional activity between affected and non-affected hemispheres was calculated in the 6th frame image of super dynamic SPECT and static SPECT image. In all 6 patients with unilateral occlusion of MCA and ICA, super dynamic SPECT images showed the better contrast of low perfusion areas in comparison with the static SPECT images. In 5 patients with subacute cerebral infarction who showed focal hyperactivities on static SPECT, focal hyperactivities (hyperperfusion or hyperemia) were displayed in 3 cases, whereas, focal hypo- or isoactivities (hypo- or isoperfusion) were shown in 2 cases on super dynamic SPECT. However, all patients with subacute cerebral infarction showed hyperfixation on static SPECT as compared with super dynamic SPECT. Although the image quality on super dynamic SPECT is not as high as that on static SPECT, cerebral hemodynamics would be detected with less backdiffusion of 99mTc-HM-PAO from the brain to blood, and with less accumulation of hydrophilic components in subacute infarct region. In conclusion, super dynamic SPECT in early distribution of 99mTc-HM-PAO using dedicated SPECT device might be helpful to detect cerebral perfusion close to true cerebral blood flow distribution.",
author = "Hiroshi Toyama and Gen Takeshita and Kaori Shibata and Masayo Nomura and Toshiteru Fujiwara and Emiko Ishikawa and Michiaki Fujiwara and Naoko Fujii and Kazutaka Ejiri and Hisato Maeda and Kazuhiro Katada and Akira Takeuchi and Sukehiko Koga",
year = "1996",
month = "12",
day = "1",
language = "English",
volume = "33",
pages = "521--529",
journal = "Kaku igaku. The Japanese journal of nuclear medicine",
issn = "0022-7854",
publisher = "Japanese Society of Nuclear Medicine",
number = "5",

}

Toyama, H, Takeshita, G, Shibata, K, Nomura, M, Fujiwara, T, Ishikawa, E, Fujiwara, M, Fujii, N, Ejiri, K, Maeda, H, Katada, K, Takeuchi, A & Koga, S 1996, 'Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area', Kakuigaku, vol. 33, no. 5, pp. 521-529.

Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area. / Toyama, Hiroshi; Takeshita, Gen; Shibata, Kaori; Nomura, Masayo; Fujiwara, Toshiteru; Ishikawa, Emiko; Fujiwara, Michiaki; Fujii, Naoko; Ejiri, Kazutaka; Maeda, Hisato; Katada, Kazuhiro; Takeuchi, Akira; Koga, Sukehiko.

In: Kakuigaku, Vol. 33, No. 5, 01.12.1996, p. 521-529.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the clinical usefulness of super dynamic99mTc-HM-PAO SPECT in ischemic cerebrovascular disease - detection of hypo- and hyperperfusion area

AU - Toyama, Hiroshi

AU - Takeshita, Gen

AU - Shibata, Kaori

AU - Nomura, Masayo

AU - Fujiwara, Toshiteru

AU - Ishikawa, Emiko

AU - Fujiwara, Michiaki

AU - Fujii, Naoko

AU - Ejiri, Kazutaka

AU - Maeda, Hisato

AU - Katada, Kazuhiro

AU - Takeuchi, Akira

AU - Koga, Sukehiko

PY - 1996/12/1

Y1 - 1996/12/1

N2 - The purpose of this study is to assess the clinical usefulness of super dynamic SPECT of 99mTc-HM-PAO. Six patients with unilateral occlusion of middle cerebral artery (MCA) or internal carotid artery (ICA) in the chronic phase, and 5 patients with subacute cerebral infarction were studied. We used a ring-type SPECT "HEADTOME." Two types of collimator were used: a high sensitivity (HS) collimator for super dynamic scan and a high resolution (HR) collimator for static scan. First, the intravenous constant infusion of 99mTc-HM-PAO (925-1480 MBq) for 1 minute was started. After 30 seconds from the beginning of the injection, we performed the 12 seconds/frame super dynamic SPECT for 2 minutes. Then, the static SPECT for 10 minutes was done. For semiquantitative analyses, differential percentage of regional activity between affected and non-affected hemispheres was calculated in the 6th frame image of super dynamic SPECT and static SPECT image. In all 6 patients with unilateral occlusion of MCA and ICA, super dynamic SPECT images showed the better contrast of low perfusion areas in comparison with the static SPECT images. In 5 patients with subacute cerebral infarction who showed focal hyperactivities on static SPECT, focal hyperactivities (hyperperfusion or hyperemia) were displayed in 3 cases, whereas, focal hypo- or isoactivities (hypo- or isoperfusion) were shown in 2 cases on super dynamic SPECT. However, all patients with subacute cerebral infarction showed hyperfixation on static SPECT as compared with super dynamic SPECT. Although the image quality on super dynamic SPECT is not as high as that on static SPECT, cerebral hemodynamics would be detected with less backdiffusion of 99mTc-HM-PAO from the brain to blood, and with less accumulation of hydrophilic components in subacute infarct region. In conclusion, super dynamic SPECT in early distribution of 99mTc-HM-PAO using dedicated SPECT device might be helpful to detect cerebral perfusion close to true cerebral blood flow distribution.

AB - The purpose of this study is to assess the clinical usefulness of super dynamic SPECT of 99mTc-HM-PAO. Six patients with unilateral occlusion of middle cerebral artery (MCA) or internal carotid artery (ICA) in the chronic phase, and 5 patients with subacute cerebral infarction were studied. We used a ring-type SPECT "HEADTOME." Two types of collimator were used: a high sensitivity (HS) collimator for super dynamic scan and a high resolution (HR) collimator for static scan. First, the intravenous constant infusion of 99mTc-HM-PAO (925-1480 MBq) for 1 minute was started. After 30 seconds from the beginning of the injection, we performed the 12 seconds/frame super dynamic SPECT for 2 minutes. Then, the static SPECT for 10 minutes was done. For semiquantitative analyses, differential percentage of regional activity between affected and non-affected hemispheres was calculated in the 6th frame image of super dynamic SPECT and static SPECT image. In all 6 patients with unilateral occlusion of MCA and ICA, super dynamic SPECT images showed the better contrast of low perfusion areas in comparison with the static SPECT images. In 5 patients with subacute cerebral infarction who showed focal hyperactivities on static SPECT, focal hyperactivities (hyperperfusion or hyperemia) were displayed in 3 cases, whereas, focal hypo- or isoactivities (hypo- or isoperfusion) were shown in 2 cases on super dynamic SPECT. However, all patients with subacute cerebral infarction showed hyperfixation on static SPECT as compared with super dynamic SPECT. Although the image quality on super dynamic SPECT is not as high as that on static SPECT, cerebral hemodynamics would be detected with less backdiffusion of 99mTc-HM-PAO from the brain to blood, and with less accumulation of hydrophilic components in subacute infarct region. In conclusion, super dynamic SPECT in early distribution of 99mTc-HM-PAO using dedicated SPECT device might be helpful to detect cerebral perfusion close to true cerebral blood flow distribution.

UR - http://www.scopus.com/inward/record.url?scp=0029888227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029888227&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 521

EP - 529

JO - Kaku igaku. The Japanese journal of nuclear medicine

JF - Kaku igaku. The Japanese journal of nuclear medicine

SN - 0022-7854

IS - 5

ER -