Evaluation of the efficacy of a lip care cream for dry lips using a new method of evaluating skin physiological functions

Keiko Nishimura, Akiko Yagami, Akiyo Sano, Tsukane Kobayashi, Shigeki Numata, Masayuki Takahashi, Takuto Miwa, Rikako Sasaki, Atsushi Fukunaga, Chikako Nishigori, Eishin Morita, Kayoko Matsunaga

Research output: Contribution to journalArticle

Abstract

We studied the use of "Nov® Lip Care Cream UV" in 50 subjects with lip dryness for 4 weeks to assess humidity retention and shading of lips. The study subjects were selected from patients with atopic dermatitis, infantile dry dermatitis, and photoallergy, who visited Fujita Health University Hospital, Rikako's Clinic of Dermatology, and Kobe University Hospital between November 2010 and May 2011. At the start and end of the trial, we measured the moisture content in the horny layer and the volume of transepidermal water loss from the lip skin. Further, to evaluate skin physiological functions, we measured the number of nucleated cells and levels of tumor necrosis factor (TNF-α) and thymic stromal lymphopoietin (TSLP) in horny layer cells collected by tape stripping. Forty-seven patients out of 50 were evaluated, and 3patients discontinued the use of the cream because of individual preferences. In regards to adverse events, 1 patient observed mild scaling and sclerosis of the lip skin, but continued cream usage. After 4 weeks of cream usage, we observed that dryness, scale, cracking, erythema, and vertical wrinkles were improved significantly. Although no significant changes were observed in the horny layer moisture content and volume of transepidermal water loss, which was measured using conventional equipment, we observed a significant decrease in the number of nucleated cells and TNF-α, and TSLP levels in the horny layer cells. These results suggest that "Nov® Lip Care Cream UV" improves cutis symptoms in dry lips. Additionally, we confirmed that horny layer analysis using tape stripping is useful for the evaluation of skin physiological functions in lips, where accurate measurements of the moisture content and volume of water loss are difficult because of their irregular shape, elasticity, and their involvement in pulmonary respiration.

Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalNishinihon Journal of Dermatology
Volume75
Issue number6
DOIs
Publication statusPublished - 2013

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Lip
Skin
Water
Skin Cream
Tumor Necrosis Factor-alpha
Photoallergic Dermatitis
Cell Count
Elasticity
Sclerosis
Dermatitis
Atopic Dermatitis
Erythema
Dermatology
Humidity
Respiration
Equipment and Supplies
Lung
Health

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Nishimura, Keiko ; Yagami, Akiko ; Sano, Akiyo ; Kobayashi, Tsukane ; Numata, Shigeki ; Takahashi, Masayuki ; Miwa, Takuto ; Sasaki, Rikako ; Fukunaga, Atsushi ; Nishigori, Chikako ; Morita, Eishin ; Matsunaga, Kayoko. / Evaluation of the efficacy of a lip care cream for dry lips using a new method of evaluating skin physiological functions. In: Nishinihon Journal of Dermatology. 2013 ; Vol. 75, No. 6. pp. 540-544.
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abstract = "We studied the use of {"}Nov{\circledR} Lip Care Cream UV{"} in 50 subjects with lip dryness for 4 weeks to assess humidity retention and shading of lips. The study subjects were selected from patients with atopic dermatitis, infantile dry dermatitis, and photoallergy, who visited Fujita Health University Hospital, Rikako's Clinic of Dermatology, and Kobe University Hospital between November 2010 and May 2011. At the start and end of the trial, we measured the moisture content in the horny layer and the volume of transepidermal water loss from the lip skin. Further, to evaluate skin physiological functions, we measured the number of nucleated cells and levels of tumor necrosis factor (TNF-α) and thymic stromal lymphopoietin (TSLP) in horny layer cells collected by tape stripping. Forty-seven patients out of 50 were evaluated, and 3patients discontinued the use of the cream because of individual preferences. In regards to adverse events, 1 patient observed mild scaling and sclerosis of the lip skin, but continued cream usage. After 4 weeks of cream usage, we observed that dryness, scale, cracking, erythema, and vertical wrinkles were improved significantly. Although no significant changes were observed in the horny layer moisture content and volume of transepidermal water loss, which was measured using conventional equipment, we observed a significant decrease in the number of nucleated cells and TNF-α, and TSLP levels in the horny layer cells. These results suggest that {"}Nov{\circledR} Lip Care Cream UV{"} improves cutis symptoms in dry lips. Additionally, we confirmed that horny layer analysis using tape stripping is useful for the evaluation of skin physiological functions in lips, where accurate measurements of the moisture content and volume of water loss are difficult because of their irregular shape, elasticity, and their involvement in pulmonary respiration.",
author = "Keiko Nishimura and Akiko Yagami and Akiyo Sano and Tsukane Kobayashi and Shigeki Numata and Masayuki Takahashi and Takuto Miwa and Rikako Sasaki and Atsushi Fukunaga and Chikako Nishigori and Eishin Morita and Kayoko Matsunaga",
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Nishimura, K, Yagami, A, Sano, A, Kobayashi, T, Numata, S, Takahashi, M, Miwa, T, Sasaki, R, Fukunaga, A, Nishigori, C, Morita, E & Matsunaga, K 2013, 'Evaluation of the efficacy of a lip care cream for dry lips using a new method of evaluating skin physiological functions', Nishinihon Journal of Dermatology, vol. 75, no. 6, pp. 540-544. https://doi.org/10.2336/nishinihonhifu.75.540

Evaluation of the efficacy of a lip care cream for dry lips using a new method of evaluating skin physiological functions. / Nishimura, Keiko; Yagami, Akiko; Sano, Akiyo; Kobayashi, Tsukane; Numata, Shigeki; Takahashi, Masayuki; Miwa, Takuto; Sasaki, Rikako; Fukunaga, Atsushi; Nishigori, Chikako; Morita, Eishin; Matsunaga, Kayoko.

In: Nishinihon Journal of Dermatology, Vol. 75, No. 6, 2013, p. 540-544.

Research output: Contribution to journalArticle

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T1 - Evaluation of the efficacy of a lip care cream for dry lips using a new method of evaluating skin physiological functions

AU - Nishimura, Keiko

AU - Yagami, Akiko

AU - Sano, Akiyo

AU - Kobayashi, Tsukane

AU - Numata, Shigeki

AU - Takahashi, Masayuki

AU - Miwa, Takuto

AU - Sasaki, Rikako

AU - Fukunaga, Atsushi

AU - Nishigori, Chikako

AU - Morita, Eishin

AU - Matsunaga, Kayoko

PY - 2013

Y1 - 2013

N2 - We studied the use of "Nov® Lip Care Cream UV" in 50 subjects with lip dryness for 4 weeks to assess humidity retention and shading of lips. The study subjects were selected from patients with atopic dermatitis, infantile dry dermatitis, and photoallergy, who visited Fujita Health University Hospital, Rikako's Clinic of Dermatology, and Kobe University Hospital between November 2010 and May 2011. At the start and end of the trial, we measured the moisture content in the horny layer and the volume of transepidermal water loss from the lip skin. Further, to evaluate skin physiological functions, we measured the number of nucleated cells and levels of tumor necrosis factor (TNF-α) and thymic stromal lymphopoietin (TSLP) in horny layer cells collected by tape stripping. Forty-seven patients out of 50 were evaluated, and 3patients discontinued the use of the cream because of individual preferences. In regards to adverse events, 1 patient observed mild scaling and sclerosis of the lip skin, but continued cream usage. After 4 weeks of cream usage, we observed that dryness, scale, cracking, erythema, and vertical wrinkles were improved significantly. Although no significant changes were observed in the horny layer moisture content and volume of transepidermal water loss, which was measured using conventional equipment, we observed a significant decrease in the number of nucleated cells and TNF-α, and TSLP levels in the horny layer cells. These results suggest that "Nov® Lip Care Cream UV" improves cutis symptoms in dry lips. Additionally, we confirmed that horny layer analysis using tape stripping is useful for the evaluation of skin physiological functions in lips, where accurate measurements of the moisture content and volume of water loss are difficult because of their irregular shape, elasticity, and their involvement in pulmonary respiration.

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