Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Ginn T. Tahimic; Nozomi Tomimatsu; Ryuichi Nishigaki; Akiko Fukuhara; Tosifusa Toda; Kozo Kaibuchi; Goshi Shiota; Mitsuo Oshimura; Akihiro Kurimasa

doi:10.1016/j.bbrc.2005.12.132

Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Ginn T. Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, Akiko Fukuhara, Tosifusa Toda, Kozo Kaibuchi, Goshi Shiota, Mitsuo Oshimura, Akihiro Kurimasa

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.

Original language	English
Pages (from-to)	1244-1250
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	340
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.12.132
Publication status	Published - 24-02-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2005.12.132

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Tahimic, C. G. T., Tomimatsu, N., Nishigaki, R., Fukuhara, A., Toda, T., Kaibuchi, K., Shiota, G., Oshimura, M., & Kurimasa, A. (2006). Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. Biochemical and Biophysical Research Communications, 340(4), 1244-1250. https://doi.org/10.1016/j.bbrc.2005.12.132

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title = "Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells",

abstract = "Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.",

author = "Tahimic, {Candice Ginn T.} and Nozomi Tomimatsu and Ryuichi Nishigaki and Akiko Fukuhara and Tosifusa Toda and Kozo Kaibuchi and Goshi Shiota and Mitsuo Oshimura and Akihiro Kurimasa",

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Tahimic, CGT, Tomimatsu, N, Nishigaki, R, Fukuhara, A, Toda, T, Kaibuchi, K, Shiota, G, Oshimura, M & Kurimasa, A 2006, 'Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells', Biochemical and Biophysical Research Communications, vol. 340, no. 4, pp. 1244-1250. https://doi.org/10.1016/j.bbrc.2005.12.132

Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells. / Tahimic, Candice Ginn T.; Tomimatsu, Nozomi; Nishigaki, Ryuichi et al.
In: Biochemical and Biophysical Research Communications, Vol. 340, No. 4, 24.02.2006, p. 1244-1250.

Research output: Contribution to journal › Article › peer-review

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T1 - Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

AU - Tahimic, Candice Ginn T.

AU - Tomimatsu, Nozomi

AU - Nishigaki, Ryuichi

AU - Fukuhara, Akiko

AU - Toda, Tosifusa

AU - Kaibuchi, Kozo

AU - Shiota, Goshi

AU - Oshimura, Mitsuo

AU - Kurimasa, Akihiro

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AB - Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.

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Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

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