Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Ginn T. Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, Akiko Fukuhara, Tosifusa Toda, Kozo Kaibuchi, Goshi Shiota, Mitsuo Oshimura, Akihiro Kurimasa

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume340
Issue number4
DOIs
Publication statusPublished - 24-02-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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