TY - JOUR
T1 - Evolution of sequence type 4821 clonal complex meningococcal strains in China from prequinolone to quinolone era, 1972-2013
AU - Guo, Qinglan
AU - Mustapha, Mustapha M.
AU - Chen, Mingliang
AU - Qu, Di
AU - Zhang, Xi
AU - Chen, Min
AU - Doi, Yohei
AU - Wang, Minggui
AU - Harrison, Lee H.
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (81673479, 81120108024, and 81601801); the Shanghai Pujiang Program (16PJD010); the Shanghai Rising-Star Program (17QA1403100); the Shanghai Medical Health Plan for Outstanding Young Talents (2017YQ039); and the 4th Three-Year Action Plan for Public Health of Shanghai (GWTD2015S01).
Funding Information:
database (http://pubmlst.org/neisseria), developed by Keith Jolley and hosted by the University of Oxford. The development of this site has been funded by the Wellcome Trust and European Union. This study also made use of the Meningitis Research Foundation Meningococcus Genome Library (http://www. meningitis.org/research/genome), developed by Public Health England, the Wellcome Trust Sanger Institute, and the University of Oxford as a collaboration. The project is funded by the Meningitis Research Foundation.
PY - 2018/4
Y1 - 2018/4
N2 - The expansion of hypervirulent sequence type 4821 clonal complex (CC4821) lineage Neisseria meningitidis bacteria has led to a shift in meningococcal disease epidemiology in China, from serogroup A (MenA) to MenC. Knowledge regarding the evolution and genetic origin of the emergent MenC strains is limited. In this study, we subjected 76 CC4821 isolates collected across China during 1972-1977 and 2005-2013 to phylogenetic analysis, traditional genotyping, or both. We show that successive recombination events within genes encoding surface antigens and acquisition of quinolone resistance mutations possibly played a role in the emergence of CC4821 as an epidemic clone in China. MenC and MenB CC4821 strains have spread across China and have been detected in several countries in different continents. Capsular switches involving serogroups B and C occurred among epidemic strains, raising concerns regarding possible increases in MenB disease, given that vaccines in use in China do not protect against MenB.
AB - The expansion of hypervirulent sequence type 4821 clonal complex (CC4821) lineage Neisseria meningitidis bacteria has led to a shift in meningococcal disease epidemiology in China, from serogroup A (MenA) to MenC. Knowledge regarding the evolution and genetic origin of the emergent MenC strains is limited. In this study, we subjected 76 CC4821 isolates collected across China during 1972-1977 and 2005-2013 to phylogenetic analysis, traditional genotyping, or both. We show that successive recombination events within genes encoding surface antigens and acquisition of quinolone resistance mutations possibly played a role in the emergence of CC4821 as an epidemic clone in China. MenC and MenB CC4821 strains have spread across China and have been detected in several countries in different continents. Capsular switches involving serogroups B and C occurred among epidemic strains, raising concerns regarding possible increases in MenB disease, given that vaccines in use in China do not protect against MenB.
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U2 - 10.3201/eid2404.171744
DO - 10.3201/eid2404.171744
M3 - Article
C2 - 29553310
AN - SCOPUS:85044209220
VL - 24
SP - 683
EP - 690
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 4
ER -