Examination of percutaneous minocycline hydrochloride injection therapy for hepatic cyst by one puncture method

Yasuhito Tanaka, Masataka Ogino, Hiroshi Tokuda, Makoto Mizuno, Manabu Yamauchi, Yoshihiko Iijima, Kouhei Hattori, Takanobu Kato, Yuuko Komatsubara, Hideaki Kato, Katsumi Hayashi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Minocycline hydrochloride (M1NO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter : 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.

Original languageEnglish
Pages (from-to)828-836
Number of pages9
JournalJapanese Journal of Gastroenterology
Volume93
Issue number11
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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