Abstract
Minocycline hydrochloride (M1NO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter : 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.
Original language | English |
---|---|
Pages (from-to) | 828-836 |
Number of pages | 9 |
Journal | Japanese Journal of Gastroenterology |
Volume | 93 |
Issue number | 11 |
Publication status | Published - 1996 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Gastroenterology