Exanthem Subitum-Associated Encephalitis: Nationwide Survey in Japan

Tetsushi Yoshikawa, Masahiro Ohashi, Fumi Miyake, Ayano Fujita, Chie Usui, Ken Sugata, Sadao Suga, Shuji Hashimoto, Yoshizo Asano

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We sought to clarify clinical features of exanthem subitum associated-encephalitis/encephalopathy, generally caused by primary human herpesvirus-6 infection in Japan. A two-part questionnaire was sent to hospitals between January 2003-December 2004. Of 3357 questionnaires, 2357 (70.2%) were returned, and 2293 (68.3%) were eligible for analysis. Eighty-six cases of exanthem subitum-associated encephalitis/encephalopathy were reported. Seventy-seven (89.5%) of 86 patients were diagnosed with human herpesvirus-6 infection by virologic examination. Although 41 (50.6%) of 81 patients had no sequelae, 38 (46.9%) had neurologic sequelae. Moreover, two fatal cases (2.5%) were reported. Pleocytosis was evident in only 4 (7.5%) of 53 patients, and cerebrospinal fluid protein levels were within normal range (23.4 ± 14.6 mg/dL S.D.) in all patients. Human herpesvirus-6 DNA was detected in 21 (53.8%) of 39 patients. Abnormal computed tomography findings were a predictor of neurologic sequelae (P = 0.0097). As a consequence of this survey, we estimate that 61.9 cases of exanthem subitum-associated encephalitis occur every year. The disease prognosis was unexpectedly poor.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalPediatric Neurology
Volume41
Issue number5
DOIs
Publication statusPublished - 01-11-2009

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Encephalitis
Exanthema
Japan
Human Herpesvirus 6
Herpesviridae Infections
Brain Diseases
Nervous System
Cerebrospinal Fluid Proteins
Leukocytosis
Reference Values
Tomography
Surveys and Questionnaires
DNA

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Yoshikawa, T., Ohashi, M., Miyake, F., Fujita, A., Usui, C., Sugata, K., ... Asano, Y. (2009). Exanthem Subitum-Associated Encephalitis: Nationwide Survey in Japan. Pediatric Neurology, 41(5), 353-358. https://doi.org/10.1016/j.pediatrneurol.2009.05.012
Yoshikawa, Tetsushi ; Ohashi, Masahiro ; Miyake, Fumi ; Fujita, Ayano ; Usui, Chie ; Sugata, Ken ; Suga, Sadao ; Hashimoto, Shuji ; Asano, Yoshizo. / Exanthem Subitum-Associated Encephalitis : Nationwide Survey in Japan. In: Pediatric Neurology. 2009 ; Vol. 41, No. 5. pp. 353-358.
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Yoshikawa, T, Ohashi, M, Miyake, F, Fujita, A, Usui, C, Sugata, K, Suga, S, Hashimoto, S & Asano, Y 2009, 'Exanthem Subitum-Associated Encephalitis: Nationwide Survey in Japan', Pediatric Neurology, vol. 41, no. 5, pp. 353-358. https://doi.org/10.1016/j.pediatrneurol.2009.05.012

Exanthem Subitum-Associated Encephalitis : Nationwide Survey in Japan. / Yoshikawa, Tetsushi; Ohashi, Masahiro; Miyake, Fumi; Fujita, Ayano; Usui, Chie; Sugata, Ken; Suga, Sadao; Hashimoto, Shuji; Asano, Yoshizo.

In: Pediatric Neurology, Vol. 41, No. 5, 01.11.2009, p. 353-358.

Research output: Contribution to journalArticle

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