Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium

Takayuki Murata, Fumi Goshima, Hiroki Takakuwa, Yukihiro Nishiyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) was excreted from infected cells into the medium. Peptide mapping analysis and lectin binding assays suggested that the gD in the medium is secreted after full glycosylation and cleavage at its C terminus. Release of HSV-2 gD was inhibited by addition of either tunicamycin or brefeldin A, suggesting that the gD in the medium was secreted through the endoplasmic reticulum and Golgi apparatus.

Original languageEnglish
Pages (from-to)2791-2795
Number of pages5
JournalJournal of General Virology
Volume83
Issue number11
DOIs
Publication statusPublished - 01-11-2002
Externally publishedYes

Fingerprint

Human Herpesvirus 2
Culture Media
Glycoproteins
Brefeldin A
Tunicamycin
Peptide Mapping
Golgi Apparatus
Glycosylation
Lectins
Endoplasmic Reticulum
glycoprotein D-herpes simplex virus type 2

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Murata, Takayuki ; Goshima, Fumi ; Takakuwa, Hiroki ; Nishiyama, Yukihiro. / Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium. In: Journal of General Virology. 2002 ; Vol. 83, No. 11. pp. 2791-2795.
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Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium. / Murata, Takayuki; Goshima, Fumi; Takakuwa, Hiroki; Nishiyama, Yukihiro.

In: Journal of General Virology, Vol. 83, No. 11, 01.11.2002, p. 2791-2795.

Research output: Contribution to journalArticle

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