Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium

Takayuki Murata, Fumi Goshima, Hiroki Takakuwa, Yukihiro Nishiyama

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Glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) was excreted from infected cells into the medium. Peptide mapping analysis and lectin binding assays suggested that the gD in the medium is secreted after full glycosylation and cleavage at its C terminus. Release of HSV-2 gD was inhibited by addition of either tunicamycin or brefeldin A, suggesting that the gD in the medium was secreted through the endoplasmic reticulum and Golgi apparatus.

Original languageEnglish
Pages (from-to)2791-2795
Number of pages5
JournalJournal of General Virology
Issue number11
Publication statusPublished - 01-11-2002


All Science Journal Classification (ASJC) codes

  • Virology

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