Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium

Takayuki Murata; Fumi Goshima; Hiroki Takakuwa; Yukihiro Nishiyama

doi:10.1099/0022-1317-83-11-2791

Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium

Takayuki Murata
, Fumi Goshima
, Hiroki Takakuwa
, Yukihiro Nishiyama

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) was excreted from infected cells into the medium. Peptide mapping analysis and lectin binding assays suggested that the gD in the medium is secreted after full glycosylation and cleavage at its C terminus. Release of HSV-2 gD was inhibited by addition of either tunicamycin or brefeldin A, suggesting that the gD in the medium was secreted through the endoplasmic reticulum and Golgi apparatus.

Original language	English
Pages (from-to)	2791-2795
Number of pages	5
Journal	Journal of General Virology
Volume	83
Issue number	11
DOIs	https://doi.org/10.1099/0022-1317-83-11-2791
Publication status	Published - 01-11-2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Virology

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10.1099/0022-1317-83-11-2791

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abstract = "Glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) was excreted from infected cells into the medium. Peptide mapping analysis and lectin binding assays suggested that the gD in the medium is secreted after full glycosylation and cleavage at its C terminus. Release of HSV-2 gD was inhibited by addition of either tunicamycin or brefeldin A, suggesting that the gD in the medium was secreted through the endoplasmic reticulum and Golgi apparatus.",

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AU - Murata, Takayuki

AU - Goshima, Fumi

AU - Takakuwa, Hiroki

AU - Nishiyama, Yukihiro

PY - 2002/11/1

Y1 - 2002/11/1

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AB - Glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) was excreted from infected cells into the medium. Peptide mapping analysis and lectin binding assays suggested that the gD in the medium is secreted after full glycosylation and cleavage at its C terminus. Release of HSV-2 gD was inhibited by addition of either tunicamycin or brefeldin A, suggesting that the gD in the medium was secreted through the endoplasmic reticulum and Golgi apparatus.

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U2 - 10.1099/0022-1317-83-11-2791

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JO - Journal of General Virology

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ER -

Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium

Abstract

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