Exogenous antigens and the stimulation of MHC class I restricted cell-mediated cytotoxicity: Possible strategies for fish vaccines

Johannes M. Dijkstra, Uwe Fischer, Yoshihiro Sawamoto, Mitsuru Ototake, Teruyuki Nakanishi

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

An MHC class I restricted cytotoxic T lymphocyte (CTL) activity assay has recently been established for rainbow trout. MHC class I restricted cytotoxicity probably plays a critical role in immunity to most viral diseases in mammals and may play a similar role in fish. Therefore, it is very important to investigate what types of vaccines can stimulate this immune response. Although logical candidates for vaccine components that can stimulate an MHC class I restricted response are live attenuated viruses and DNA vaccines, these materials are generally not allowed in fish for commercial vaccine use due to potential safety issues. In mammals, however, a number of interesting vaccination strategies based on exogenous antigens that stimulate MHC class I restricted cytotoxicity have been described. Several of these strategies are discussed in this review in the context of fish vaccination.

Original languageEnglish
Pages (from-to)437-458
Number of pages22
JournalFish and Shellfish Immunology
Volume11
Issue number6
DOIs
Publication statusPublished - 08-2001

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

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