Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog

Hisateru Yamaguchi, Yoshikazu Kurosawa, Keiichiro Hashimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume250
Issue number3
DOIs
Publication statusPublished - 29-09-1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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