Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume250
Issue number3
DOIs
Publication statusPublished - 29-09-1998

Fingerprint

MHC Class I Genes
Major Histocompatibility Complex
Genes
DNA Transposable Elements
Molecules
Introns
Vertebrates

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

@article{f564127045e44ff997946bcec0e519cf,
title = "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog",
abstract = "MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.",
author = "Hisateru Yamaguchi and Yoshikazu Kurosawa and Keiichiro Hashimoto",
year = "1998",
month = "9",
day = "29",
doi = "10.1006/bbrc.1998.9353",
language = "English",
volume = "250",
pages = "558--564",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog

AU - Yamaguchi, Hisateru

AU - Kurosawa, Yoshikazu

AU - Hashimoto, Keiichiro

PY - 1998/9/29

Y1 - 1998/9/29

N2 - MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.

AB - MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.

UR - http://www.scopus.com/inward/record.url?scp=0032578585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032578585&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1998.9353

DO - 10.1006/bbrc.1998.9353

M3 - Article

C2 - 9784382

AN - SCOPUS:0032578585

VL - 250

SP - 558

EP - 564

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -