TY - JOUR
T1 - Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog
AU - Yamaguchi, Hisateru
AU - Kurosawa, Yoshikazu
AU - Hashimoto, Keiichiro
N1 - Funding Information:
This work was supported in part by grants from the Ministry of Education, Science, and Culture of Japan; the Ministry of Agriculture, Forestry, and Fisheries of Japan; the Ministry of Health and Welfare of Japan; and Fujita Health University.
PY - 1998/9/29
Y1 - 1998/9/29
N2 - MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.
AB - MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the α1 and α2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.
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U2 - 10.1006/bbrc.1998.9353
DO - 10.1006/bbrc.1998.9353
M3 - Article
C2 - 9784382
AN - SCOPUS:0032578585
SN - 0006-291X
VL - 250
SP - 558
EP - 564
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -