Expansion of genes that encode MHC class I molecules in cyprinid fishes

K. Okamura, T. Nakanishi, Y. Kurosawa, K. Hashimoto

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We have analyzed the genomic genes and the mRNA that encode MHC class I molecules in cyprinid fishes, namely, the ginbuna crucian carp (Carassius auratus langsdorfii) and the carp (Cyprinus carpio). The presence of several distinct class I genes was revealed in the genome of cyprinid fishes, and distinct class I genes that are expressed in carp cells were identified. The sequences of the α3 domain of these class I genes are relatively well conserved, whereas the sequences of the respective α1 and α2 domains have diverged from one another. A comparison of the sequences expressed in carp with the sequences of the human classical class I molecules revealed that several amino acids in the peptide-binding region, including those that have been proposed to interact with antigenic peptide termini, are highly conserved. The present study demonstrated a dynamic expansion of the genes that encode MHC class I molecules in teleost fish whose ancestor branched off from the vertebrate line leading to mammals more than 400 million years ago.

Original languageEnglish
Pages (from-to)188-200
Number of pages13
JournalJournal of Immunology
Volume151
Issue number1
Publication statusPublished - 01-01-1993

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MHC Class I Genes
Carps
Fishes
Peptides
Goldfish
Conserved Sequence
Vertebrates
Mammals
Genome
Amino Acids
Messenger RNA
Genes

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Okamura, K. ; Nakanishi, T. ; Kurosawa, Y. ; Hashimoto, K. / Expansion of genes that encode MHC class I molecules in cyprinid fishes. In: Journal of Immunology. 1993 ; Vol. 151, No. 1. pp. 188-200.
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Okamura, K, Nakanishi, T, Kurosawa, Y & Hashimoto, K 1993, 'Expansion of genes that encode MHC class I molecules in cyprinid fishes', Journal of Immunology, vol. 151, no. 1, pp. 188-200.

Expansion of genes that encode MHC class I molecules in cyprinid fishes. / Okamura, K.; Nakanishi, T.; Kurosawa, Y.; Hashimoto, K.

In: Journal of Immunology, Vol. 151, No. 1, 01.01.1993, p. 188-200.

Research output: Contribution to journalArticle

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