Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats

Ayako Watanabe; Yoshihiro Kadota; Hijiri Yokoyama; Shunya Tsuruda; Rina Kamio; Takumi Tochio; Yoshiharu Shimomura; Yasuyuki Kitaura

doi:10.3390/foods9010004

Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats

Ayako Watanabe, Yoshihiro Kadota, Hijiri Yokoyama, Shunya Tsuruda, Rina Kamio, Takumi Tochio, Yoshiharu Shimomura, Yasuyuki Kitaura

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

1-Kestose is a non-digestible oligosaccharide consisting of glucose linked to two fructose units. While 1-kestose is not digested in the small intestine of mammals, it is fermented in the ceca and colon, where the growth of bifidobacteria is promoted. In the present study, we assessed the threshold dose of dietary 1-kestose that increased cecal bifidobacterial levels in rats. Rats were fed experimental diets containing 0% to 0.3% 1-kestose for four weeks. The levels of the genus Bifidobacterium and total gut bacteria were significantly increased in cecal samples of rats fed the 0.3% 1-kestose diet. Further, a significant correlation between the dose of 1-kestose and the levels of cecal Bifidobacterium and total gut bacteria was observed. The minimum dose of dietary 1-kestose to induce significant bifidogenic activity in rats was 0.3% by weight in the diet.

Original language	English
Article number	4
Journal	Foods
Volume	9
Issue number	1
DOIs	https://doi.org/10.3390/foods9010004
Publication status	Published - 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Food Science
Microbiology
Health(social science)
Health Professions (miscellaneous)
Plant Science

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10.3390/foods9010004

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title = "Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats",

abstract = "1-Kestose is a non-digestible oligosaccharide consisting of glucose linked to two fructose units. While 1-kestose is not digested in the small intestine of mammals, it is fermented in the ceca and colon, where the growth of bifidobacteria is promoted. In the present study, we assessed the threshold dose of dietary 1-kestose that increased cecal bifidobacterial levels in rats. Rats were fed experimental diets containing 0% to 0.3% 1-kestose for four weeks. The levels of the genus Bifidobacterium and total gut bacteria were significantly increased in cecal samples of rats fed the 0.3% 1-kestose diet. Further, a significant correlation between the dose of 1-kestose and the levels of cecal Bifidobacterium and total gut bacteria was observed. The minimum dose of dietary 1-kestose to induce significant bifidogenic activity in rats was 0.3% by weight in the diet.",

author = "Ayako Watanabe and Yoshihiro Kadota and Hijiri Yokoyama and Shunya Tsuruda and Rina Kamio and Takumi Tochio and Yoshiharu Shimomura and Yasuyuki Kitaura",

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year = "2020",

doi = "10.3390/foods9010004",

language = "English",

volume = "9",

journal = "Foods",

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T1 - Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats

AU - Watanabe, Ayako

AU - Kadota, Yoshihiro

AU - Yokoyama, Hijiri

AU - Tsuruda, Shunya

AU - Kamio, Rina

AU - Tochio, Takumi

AU - Shimomura, Yoshiharu

AU - Kitaura, Yasuyuki

PY - 2020

Y1 - 2020

N2 - 1-Kestose is a non-digestible oligosaccharide consisting of glucose linked to two fructose units. While 1-kestose is not digested in the small intestine of mammals, it is fermented in the ceca and colon, where the growth of bifidobacteria is promoted. In the present study, we assessed the threshold dose of dietary 1-kestose that increased cecal bifidobacterial levels in rats. Rats were fed experimental diets containing 0% to 0.3% 1-kestose for four weeks. The levels of the genus Bifidobacterium and total gut bacteria were significantly increased in cecal samples of rats fed the 0.3% 1-kestose diet. Further, a significant correlation between the dose of 1-kestose and the levels of cecal Bifidobacterium and total gut bacteria was observed. The minimum dose of dietary 1-kestose to induce significant bifidogenic activity in rats was 0.3% by weight in the diet.

AB - 1-Kestose is a non-digestible oligosaccharide consisting of glucose linked to two fructose units. While 1-kestose is not digested in the small intestine of mammals, it is fermented in the ceca and colon, where the growth of bifidobacteria is promoted. In the present study, we assessed the threshold dose of dietary 1-kestose that increased cecal bifidobacterial levels in rats. Rats were fed experimental diets containing 0% to 0.3% 1-kestose for four weeks. The levels of the genus Bifidobacterium and total gut bacteria were significantly increased in cecal samples of rats fed the 0.3% 1-kestose diet. Further, a significant correlation between the dose of 1-kestose and the levels of cecal Bifidobacterium and total gut bacteria was observed. The minimum dose of dietary 1-kestose to induce significant bifidogenic activity in rats was 0.3% by weight in the diet.

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DO - 10.3390/foods9010004

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JO - Foods

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ER -

Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats

Abstract

All Science Journal Classification (ASJC) codes

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