Experimental Induction of Uterine Cancer in Rats by N-ethyl-N'-nitro-N-nitrosoguanidine Dissolved in Polyethylene Glycol

H. Ogino, M. Fujimoto, H. Oshiro, K. Matsumoto, M. Funahashi, C. Kaneko, I. Hirono

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

In the present experiment we attempted to experimentally induce uterine cancer in rats by injecting into the uterine cavity N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) dissolved in polyethylene glycol (PEG). Fifty-nine female F-344 rats, 7–8 weeks old, were divided into three groups and each received in the left uterine cavity with laparotomy a single dose of ENNG dissolved in PEG according to the following schedule: Group 1 received 75 mg ENNG/kg body wt.; Group 2 had 20 mg ENNG/kg body wt.: and Group 3 was given only PEG. In Group 1 it was observed that adenocarcinoma and sarcoma were present in the uterine corpus while squamous cell carcinoma occurred in the uterine cervix. In Group 2, although tumors such as adenocarcinoma, adenoma and sarcoma were observed in the uterine corpus, no tumor was present in the uterine cervix. No tumor growth whatsoever was observed in Group 3. From the above results it is apparent that the present method is an efficient means for experimentally inducing uterine cancer and that the site of tumor generation varies according to the concentration of ENNG administered.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalPathology Research and Practice
Volume185
Issue number2
DOIs
Publication statusPublished - 01-01-1989

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Experimental Induction of Uterine Cancer in Rats by N-ethyl-N'-nitro-N-nitrosoguanidine Dissolved in Polyethylene Glycol'. Together they form a unique fingerprint.

Cite this