Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver

T. Fukuoka, Y. Nakajima, H. Nakano, Takashi Kenmochi, R. Hayashi, S. Suzuki, H. Amemiya

Research output: Contribution to journalArticle

Abstract

Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

Original languageEnglish
Pages (from-to)1474-1480
Number of pages7
JournalNippon Geka Gakkai zasshi
Volume93
Issue number12
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Platelet Activating Factor
Shock
Liver
Liver Failure
Control Groups
Ischemia
Constriction
Arterial Pressure
Dogs
Transplants
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Fukuoka, T., Nakajima, Y., Nakano, H., Kenmochi, T., Hayashi, R., Suzuki, S., & Amemiya, H. (1992). Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. Nippon Geka Gakkai zasshi, 93(12), 1474-1480.
Fukuoka, T. ; Nakajima, Y. ; Nakano, H. ; Kenmochi, Takashi ; Hayashi, R. ; Suzuki, S. ; Amemiya, H. / Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. In: Nippon Geka Gakkai zasshi. 1992 ; Vol. 93, No. 12. pp. 1474-1480.
@article{41c373264eba4e6fa092be2cce2cb90c,
title = "Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver",
abstract = "Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70{\%} of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.",
author = "T. Fukuoka and Y. Nakajima and H. Nakano and Takashi Kenmochi and R. Hayashi and S. Suzuki and H. Amemiya",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "93",
pages = "1474--1480",
journal = "Nihon Geka Gakkai zasshi",
issn = "0301-4894",
publisher = "Nihon Geka Gakkai",
number = "12",

}

Fukuoka, T, Nakajima, Y, Nakano, H, Kenmochi, T, Hayashi, R, Suzuki, S & Amemiya, H 1992, 'Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver', Nippon Geka Gakkai zasshi, vol. 93, no. 12, pp. 1474-1480.

Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver. / Fukuoka, T.; Nakajima, Y.; Nakano, H.; Kenmochi, Takashi; Hayashi, R.; Suzuki, S.; Amemiya, H.

In: Nippon Geka Gakkai zasshi, Vol. 93, No. 12, 01.01.1992, p. 1474-1480.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver

AU - Fukuoka, T.

AU - Nakajima, Y.

AU - Nakano, H.

AU - Kenmochi, Takashi

AU - Hayashi, R.

AU - Suzuki, S.

AU - Amemiya, H.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

AB - Ischemic hepatic failure is often accompanied by systemic circulatory failure. In hepatic graft failure, this circulatory derangement is reported to be cured by retransplantation. This suggests that ischemic liver might release some substance which causes circulatory depression. In the present study, the role of platelet activating factor (PAF) in systemic circulatory failure after liver ischemia was investigated. Partial hepatic ischemia was induced in ten dogs by clamping the afferent vessels to almost 70% of the liver for 60 minutes, and non-ischemic lobes were resected after declamping. Five were pretreated with 3 mg/kg of PAF antagonist (CV6209) i.v. (PAF antagonist group), and the others were pretreated with saline (control group). The mean arterial pressure markedly decreased after declamping in control group (89 +/- 25mmHg 25 min after declamping), but it did not fall in PAF antagonist group (155 +/- 221mmHg). Three died from either shock or hepatic failure within a week in control group, but none died in PAF antagonist group. In conclusion, ischemic liver was suggested to release PAF and depress systemic circulation. And a PAF antagonist was expected to be an effective drug for the circulatory derangement caused by ischemic liver.

UR - http://www.scopus.com/inward/record.url?scp=0027023037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027023037&partnerID=8YFLogxK

M3 - Article

C2 - 1287460

AN - SCOPUS:0027023037

VL - 93

SP - 1474

EP - 1480

JO - Nihon Geka Gakkai zasshi

JF - Nihon Geka Gakkai zasshi

SN - 0301-4894

IS - 12

ER -