Abstract
Occupational trichloroethylene (TCE) exposure can induce life-threatening generalized dermatitis accompanied by hepatitis: TCE hypersensitivity syndrome (HS). Since the patients’ exposure levels have not been fully clarified, this study estimated end-of-shift urinary concentrations of trichloroacetic acid (TCA) and their lower limit below which the disease occurrence was rare. TCA concentration was measured in 78 TCE HS patients whose urine was collected at admission between 2nd and 14th d after their last shift. Then a linear regression model was used to calculate the mean TCA concentration with 95% confidence interval (95% CI) and 95% prediction interval (95% PI) in the end-of-shift urine. The estimated mean concentration was 83 (95% CI, 49–140) mg/l with 95% PI 9.6–720 mg/l. TCA concentrations were also measured in the end-of-shift urine of 38 healthy workers involved in the same job as were the patients. The geometric mean and its 95% CI were 127 mg/l and 16–984 mg/l, respectively. The exposure levels in HS patients might have thus overlapped with those in workers without HS. Accordingly, it was suggested that HS occurred in the environment where the workers were exposed to the TCE concentration corresponding to the urinary TCA concentration as low as 10 mg/l.
| Original language | English |
|---|---|
| Pages (from-to) | 300-307 |
| Number of pages | 8 |
| Journal | Industrial Health |
| Volume | 56 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-01-2018 |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
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Exposure reconstruction of trichloroethylene among patients with occupational trichloroethylene hypersensitivity syndrome. / Nakajima, Tamie; Wang, Hailan; Ito, Yuki; Naito, Hisao; Wang, Dong; Zhao, Na; Li, Hongling; Qiu, Xinxiang; Xia, Lihua; Chen, Jiabin; Wu, Qifeng; Li, Laiyu; Huang, Hanlin; Kamijima, Michihiro.
In: Industrial Health, Vol. 56, No. 4, 01.01.2018, p. 300-307.Research output: Contribution to journal › Article
TY - JOUR
T1 - Exposure reconstruction of trichloroethylene among patients with occupational trichloroethylene hypersensitivity syndrome
AU - Nakajima, Tamie
AU - Wang, Hailan
AU - Ito, Yuki
AU - Naito, Hisao
AU - Wang, Dong
AU - Zhao, Na
AU - Li, Hongling
AU - Qiu, Xinxiang
AU - Xia, Lihua
AU - Chen, Jiabin
AU - Wu, Qifeng
AU - Li, Laiyu
AU - Huang, Hanlin
AU - Kamijima, Michihiro
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Occupational trichloroethylene (TCE) exposure can induce life-threatening generalized dermatitis accompanied by hepatitis: TCE hypersensitivity syndrome (HS). Since the patients’ exposure levels have not been fully clarified, this study estimated end-of-shift urinary concentrations of trichloroacetic acid (TCA) and their lower limit below which the disease occurrence was rare. TCA concentration was measured in 78 TCE HS patients whose urine was collected at admission between 2nd and 14th d after their last shift. Then a linear regression model was used to calculate the mean TCA concentration with 95% confidence interval (95% CI) and 95% prediction interval (95% PI) in the end-of-shift urine. The estimated mean concentration was 83 (95% CI, 49–140) mg/l with 95% PI 9.6–720 mg/l. TCA concentrations were also measured in the end-of-shift urine of 38 healthy workers involved in the same job as were the patients. The geometric mean and its 95% CI were 127 mg/l and 16–984 mg/l, respectively. The exposure levels in HS patients might have thus overlapped with those in workers without HS. Accordingly, it was suggested that HS occurred in the environment where the workers were exposed to the TCE concentration corresponding to the urinary TCA concentration as low as 10 mg/l.
AB - Occupational trichloroethylene (TCE) exposure can induce life-threatening generalized dermatitis accompanied by hepatitis: TCE hypersensitivity syndrome (HS). Since the patients’ exposure levels have not been fully clarified, this study estimated end-of-shift urinary concentrations of trichloroacetic acid (TCA) and their lower limit below which the disease occurrence was rare. TCA concentration was measured in 78 TCE HS patients whose urine was collected at admission between 2nd and 14th d after their last shift. Then a linear regression model was used to calculate the mean TCA concentration with 95% confidence interval (95% CI) and 95% prediction interval (95% PI) in the end-of-shift urine. The estimated mean concentration was 83 (95% CI, 49–140) mg/l with 95% PI 9.6–720 mg/l. TCA concentrations were also measured in the end-of-shift urine of 38 healthy workers involved in the same job as were the patients. The geometric mean and its 95% CI were 127 mg/l and 16–984 mg/l, respectively. The exposure levels in HS patients might have thus overlapped with those in workers without HS. Accordingly, it was suggested that HS occurred in the environment where the workers were exposed to the TCE concentration corresponding to the urinary TCA concentration as low as 10 mg/l.
UR - http://www.scopus.com/inward/record.url?scp=85050822061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050822061&partnerID=8YFLogxK
U2 - 10.2486/indhealth.2017-0202
DO - 10.2486/indhealth.2017-0202
M3 - Article
C2 - 29503390
AN - SCOPUS:85050822061
VL - 56
SP - 300
EP - 307
JO - Industrial Health
JF - Industrial Health
SN - 0019-8366
IS - 4
ER -