Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice

Eun Joo Shin, Hoon Jeong Ji, Ji Kim Hyun, Choon Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalJournal of Pharmacological Sciences
Volume105
Issue number4
DOIs
Publication statusPublished - 01-12-2007
Externally publishedYes

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Dopamine D1 Receptors
Magnetic Fields
Locomotion
Sulpiride
Dopamine

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Shin, Eun Joo ; Ji, Hoon Jeong ; Hyun, Ji Kim ; Jang, Choon Gon ; Yamada, Kiyofumi ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. In: Journal of Pharmacological Sciences. 2007 ; Vol. 105, No. 4. pp. 367-371.
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Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. / Shin, Eun Joo; Ji, Hoon Jeong; Hyun, Ji Kim; Jang, Choon Gon; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 105, No. 4, 01.12.2007, p. 367-371.

Research output: Contribution to journalArticle

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