TY - JOUR
T1 - Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice
AU - Shin, Eun Joo
AU - Ji, Hoon Jeong
AU - Hyun, Ji Kim
AU - Jang, Choon Gon
AU - Yamada, Kiyofumi
AU - Nabeshima, Toshitaka
AU - Kim, Hyoung Chun
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.
AB - We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D1-like receptor antagonist, but not with sulpiride, a dopaminergic D2-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.
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U2 - 10.1254/jphs.SC0070348
DO - 10.1254/jphs.SC0070348
M3 - Article
C2 - 18094524
AN - SCOPUS:37549053264
SN - 1347-8613
VL - 105
SP - 367
EP - 371
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 4
ER -