Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine

Huynh Nhu Mai, Naveen Sharma, Eun Joo Shin, Bao Trong Nguyen, Phuong Tram Nguyen, Ji Hoon Jeong, Eun Hee Cho, Yu Jeung Lee, Nam Hun Kim, Choon Gon Jang, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have previously demonstrated that repeated treatment with methamphetamine (MA) results in a recognition memory impairment via upregulation of protein kinase C (PKC) δ and downregulation of the glutathione peroxidase-1 (GPx-1)-dependent antioxidant system. We also demonstrated that far-infrared ray (FIR) attenuates acute restraint stress via induction of the GPx-1 gene. Herein, we investigated whether exposure to FIR modulates MA-induced recognition memory impairment in male mice, and whether cognitive potentials mediated by FIR require modulation of the PKCδ gene, extracellular signal-regulated kinase (ERK) 1/2, and glutathione-dependent system. Repeated treatment with MA significantly increased PKCδ expression and its phosphorylation out of PKC isoenzymes (i.e., PKCα, PKCβI, PKCβII, PKCζ, and PKCδ expression) in the prefrontal cortex of mice. Exposure to FIR significantly attenuated MA-induced increase in phospho-PKCδ and decrease in phospho-ERK 1/2. In addition, FIR further facilitated the nuclear factor E2-related factor 2 (Nrf2)-dependent glutathione synthetic system. Moreover, L-buthionine-(S, R)-sulfoximine, an inhibitor of glutathione synthesis, counteracted the FIR-mediated phospho-ERK 1/2 induction and memory-enhancing activity against MA insult. More important, positive effects of FIR are comparable to those of genetic depletion of PKCδ or the antipsychotic clozapine. Our results indicate that FIR protects against MA-induced memory impairment via activations of the Nrf2-dependent glutathione synthetic system, and ERK 1/2 signaling by inhibition of the PKCδ gene.

Original languageEnglish
Pages (from-to)1294-1310
Number of pages17
JournalJournal of Neuroscience Research
Volume96
Issue number7
DOIs
Publication statusPublished - 07-2018

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine'. Together they form a unique fingerprint.

  • Cite this

    Mai, H. N., Sharma, N., Shin, E. J., Nguyen, B. T., Nguyen, P. T., Jeong, J. H., Cho, E. H., Lee, Y. J., Kim, N. H., Jang, C. G., Nabeshima, T., & Kim, H. C. (2018). Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine. Journal of Neuroscience Research, 96(7), 1294-1310. https://doi.org/10.1002/jnr.24228