Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer: Association with tumor grade and CA-125

Hideo Kazeto, Seiji Nomura, Norio Ito, Tomomi Ito, Yoshiteru Watanabe, Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Koji Tamakoshi, Akira Hattori, Fumitaka Kikkawa, Tetsuro Nagasaka, Masafumi Tsujimoto, Shigehiko Mizutani

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8 Citations (Scopus)

Abstract

Adipocyte-derived leucine aminopeptidase (A-LAP) is a novel zinc-metallopeptidase involved in angiotensin II (AngII) metabolism, cell migration and antigen presentation. These functions are implicated in the progression of cancer, whereas A-LAP expression and involvement have not been studied in any type of cancer. We investigated the expression of A-LAP in endometrial cancer as well as its association with angiogenesis and clinicopathological features. Immunohistochemical staining of 58 endometrial endometrioid adenocarcinoma specimens revealed that 37 were A-LAP immunoreactive. We also found that A-LAP staining correlated with histological tumor grade in a significant and reverse manner. In addition, serum CA-125 levels in patients with A-LAP positive cancers were significantly higher. However, contrary to our hypothesis that A-LAP suppresses angiogenic activity via AngII metabolism, A-LAP expression was not associated with the microvessel count determined by CD34 immunostaining. Our results suggest that A-LAP is involved in endometrial cancer cell growth and differentiation. However, further studies, especially of the biological roles of A-LAP, are required to confirm this notion.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalTumor Biology
Volume24
Issue number4
DOIs
Publication statusPublished - 16-12-2003

All Science Journal Classification (ASJC) codes

  • Cancer Research

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    Kazeto, H., Nomura, S., Ito, N., Ito, T., Watanabe, Y., Kajiyama, H., Shibata, K., Ino, K., Tamakoshi, K., Hattori, A., Kikkawa, F., Nagasaka, T., Tsujimoto, M., & Mizutani, S. (2003). Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer: Association with tumor grade and CA-125. Tumor Biology, 24(4), 203-208. https://doi.org/10.1159/000074431