Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

Osamu Nikkuni; Kyoichi Kaira; Minoru Toyoda; Masato Shino; Koichi Sakakura; Katsumasa Takahashi; Hideyuki Tominaga; Noboru Oriuchi; Masami Suzuki; Misa Iijima; Takayuki Asao; Masahiko Nishiyama; Shushi Nagamori; Yoshikatsu Kanai; Tetsunari Oyama; Kazuaki Chikamatsu

doi:10.1007/s12253-015-9954-3

Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

Osamu Nikkuni
, Kyoichi Kaira
, Minoru Toyoda
, Masato Shino
, Koichi Sakakura
, Katsumasa Takahashi
, Hideyuki Tominaga
, Noboru Oriuchi
, Masami Suzuki
, Misa Iijima
, Takayuki Asao
, Masahiko Nishiyama
, Shushi Nagamori
, Yoshikatsu Kanai
, Tetsunari Oyama
, Kazuaki Chikamatsu

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The aim of this study is to evaluate the clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with advanced laryngeal squamous cell carcinoma (LSCC). A total of 73 patients with advanced LSCC were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by CD34 and p53. A positive LAT1, 4F2hc and ASCT2 expression (staining more than a quarter) in the primary sites were recognized in 85, 80 and 45 %, respectively, and a high LAT1, 4F2hc and ASCT2 expression (staining more than a half) yielded 48, 31 and 18 %, respectively. High expression of LAT1 was significantly associated with lymph node metastasis, 4F2hc, ASCT2, Ki-67 and p53. The expression of LAT1 was significantly correlated with ASCT2, 4F2hc, cell proliferation, and MVD. By univariate analysis, there was no statistically significant relationship between LAT1 expression and prognosis in advanced LSCC. LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. Our study suggests that the expression of LAT1 plays a crucial role in the metastasis and tumor progression in advanced LSCC.

Original language	English
Pages (from-to)	1175-1181
Number of pages	7
Journal	Pathology and Oncology Research
Volume	21
Issue number	4
DOIs	https://doi.org/10.1007/s12253-015-9954-3
Publication status	Published - 28-09-2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Oncology
Cancer Research

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10.1007/s12253-015-9954-3

Cite this

Nikkuni, O., Kaira, K., Toyoda, M., Shino, M., Sakakura, K., Takahashi, K., Tominaga, H., Oriuchi, N., Suzuki, M., Iijima, M., Asao, T., Nishiyama, M., Nagamori, S., Kanai, Y., Oyama, T., & Chikamatsu, K. (2015). Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma. Pathology and Oncology Research, 21(4), 1175-1181. https://doi.org/10.1007/s12253-015-9954-3

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title = "Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma",

abstract = "The aim of this study is to evaluate the clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with advanced laryngeal squamous cell carcinoma (LSCC). A total of 73 patients with advanced LSCC were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by CD34 and p53. A positive LAT1, 4F2hc and ASCT2 expression (staining more than a quarter) in the primary sites were recognized in 85, 80 and 45 \%, respectively, and a high LAT1, 4F2hc and ASCT2 expression (staining more than a half) yielded 48, 31 and 18 \%, respectively. High expression of LAT1 was significantly associated with lymph node metastasis, 4F2hc, ASCT2, Ki-67 and p53. The expression of LAT1 was significantly correlated with ASCT2, 4F2hc, cell proliferation, and MVD. By univariate analysis, there was no statistically significant relationship between LAT1 expression and prognosis in advanced LSCC. LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. Our study suggests that the expression of LAT1 plays a crucial role in the metastasis and tumor progression in advanced LSCC.",

keywords = "ASCT2, CD98, Imunohistochemistry, Larynx, LAT1, Prognostic factor",

author = "Osamu Nikkuni and Kyoichi Kaira and Minoru Toyoda and Masato Shino and Koichi Sakakura and Katsumasa Takahashi and Hideyuki Tominaga and Noboru Oriuchi and Masami Suzuki and Misa Iijima and Takayuki Asao and Masahiko Nishiyama and Shushi Nagamori and Yoshikatsu Kanai and Tetsunari Oyama and Kazuaki Chikamatsu",

note = "Publisher Copyright: {\textcopyright} 2015, Ar{\'a}nyi Lajos Foundation.",

year = "2015",

month = sep,

day = "28",

doi = "10.1007/s12253-015-9954-3",

language = "English",

volume = "21",

pages = "1175--1181",

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Nikkuni, O, Kaira, K, Toyoda, M, Shino, M, Sakakura, K, Takahashi, K, Tominaga, H, Oriuchi, N, Suzuki, M, Iijima, M, Asao, T, Nishiyama, M, Nagamori, S, Kanai, Y, Oyama, T & Chikamatsu, K 2015, 'Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma', Pathology and Oncology Research, vol. 21, no. 4, pp. 1175-1181. https://doi.org/10.1007/s12253-015-9954-3

TY - JOUR

T1 - Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

AU - Nikkuni, Osamu

AU - Kaira, Kyoichi

AU - Toyoda, Minoru

AU - Shino, Masato

AU - Sakakura, Koichi

AU - Takahashi, Katsumasa

AU - Tominaga, Hideyuki

AU - Oriuchi, Noboru

AU - Suzuki, Masami

AU - Iijima, Misa

AU - Asao, Takayuki

AU - Nishiyama, Masahiko

AU - Nagamori, Shushi

AU - Kanai, Yoshikatsu

AU - Oyama, Tetsunari

AU - Chikamatsu, Kazuaki

PY - 2015/9/28

Y1 - 2015/9/28

N2 - The aim of this study is to evaluate the clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with advanced laryngeal squamous cell carcinoma (LSCC). A total of 73 patients with advanced LSCC were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by CD34 and p53. A positive LAT1, 4F2hc and ASCT2 expression (staining more than a quarter) in the primary sites were recognized in 85, 80 and 45 %, respectively, and a high LAT1, 4F2hc and ASCT2 expression (staining more than a half) yielded 48, 31 and 18 %, respectively. High expression of LAT1 was significantly associated with lymph node metastasis, 4F2hc, ASCT2, Ki-67 and p53. The expression of LAT1 was significantly correlated with ASCT2, 4F2hc, cell proliferation, and MVD. By univariate analysis, there was no statistically significant relationship between LAT1 expression and prognosis in advanced LSCC. LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. Our study suggests that the expression of LAT1 plays a crucial role in the metastasis and tumor progression in advanced LSCC.

AB - The aim of this study is to evaluate the clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with advanced laryngeal squamous cell carcinoma (LSCC). A total of 73 patients with advanced LSCC were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by CD34 and p53. A positive LAT1, 4F2hc and ASCT2 expression (staining more than a quarter) in the primary sites were recognized in 85, 80 and 45 %, respectively, and a high LAT1, 4F2hc and ASCT2 expression (staining more than a half) yielded 48, 31 and 18 %, respectively. High expression of LAT1 was significantly associated with lymph node metastasis, 4F2hc, ASCT2, Ki-67 and p53. The expression of LAT1 was significantly correlated with ASCT2, 4F2hc, cell proliferation, and MVD. By univariate analysis, there was no statistically significant relationship between LAT1 expression and prognosis in advanced LSCC. LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. Our study suggests that the expression of LAT1 plays a crucial role in the metastasis and tumor progression in advanced LSCC.

KW - ASCT2

KW - CD98

KW - Imunohistochemistry

KW - Larynx

KW - LAT1

KW - Prognostic factor

UR - https://www.scopus.com/pages/publications/84940447276

UR - https://www.scopus.com/pages/publications/84940447276#tab=citedBy

U2 - 10.1007/s12253-015-9954-3

DO - 10.1007/s12253-015-9954-3

M3 - Article

C2 - 26024742

AN - SCOPUS:84940447276

SN - 1219-4956

VL - 21

SP - 1175

EP - 1181

JO - Pathology and Oncology Research

JF - Pathology and Oncology Research

IS - 4

ER -

Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma

Abstract

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