Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils

Zhiyuan Li, Yasuharu Niwa, Kazuhito Rokutan, Yutaka Nakaya

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


In situ hybridization and immunohistochemical examinations of surgically resected specimens of human hyperplastic tonsils showed that macrophages in the germinal center and mast cells in the parafollicular and interfollicular areas expressed the transcript and protein of endothelin (ET)-1, but not ET-2 and ET-3. The macrophages appeared to be activated, since they possessed significant amounts of inducible nitric oxide synthase. None of these expressions was observed in normal tonsil. Our results suggest that the over-production of ET-1 by macrophages and mast cells may be involved in the pathogenesis of hyperplastic tonsils. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalFEBS Letters
Issue number3
Publication statusPublished - 03-09-1999

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'Expression of endothelin-1 in macrophages and mast cells in hyperplastic human tonsils'. Together they form a unique fingerprint.

Cite this