Expression of erbB receptors mRNA in thyroid tissues

Seiya Kato, Takako Kobayashi, Kouji Yamada, Kazuhiro Nishii, Hirohide Sawada, Hiroshi Ishiguro, Mitsuyasu Itoh, Hiroomi Funahashi, Akio Nagasaka

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan. ErbB2 is associated with aggressive cancers and is used as a biological marker for the disease; Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) analyses have shown it to be increased in Graves' disease. Additional studies indicated a similar result in papillary carcinoma cells; mRNAs of erbB2 and erbB3 were increased but erbB4 mRNA was decreased, suggesting distorted erbB expression may be associated with tumorigenesis. However, only erbB2 overexpression is associated with Graves' disease. These data further implicate transmembrane-type receptors in tumorigenesis in the thyroid.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalBiochimica et Biophysica Acta - General Subjects
Volume1673
Issue number3
DOIs
Publication statusPublished - 04-08-2004

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Graves Disease
Thyroid Gland
Carcinogenesis
Tissue
Messenger RNA
Papillary Carcinoma
Epidermal Growth Factor Receptor
Northern Blotting
Reverse Transcription
Polymerase chain reaction
Neoplasms
Transcription
Biomarkers
Tumors
Polymerase Chain Reaction
Cells
ErbB Receptors

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Kato, S., Kobayashi, T., Yamada, K., Nishii, K., Sawada, H., Ishiguro, H., ... Nagasaka, A. (2004). Expression of erbB receptors mRNA in thyroid tissues. Biochimica et Biophysica Acta - General Subjects, 1673(3), 194-200. https://doi.org/10.1016/j.bbagen.2004.04.016
Kato, Seiya ; Kobayashi, Takako ; Yamada, Kouji ; Nishii, Kazuhiro ; Sawada, Hirohide ; Ishiguro, Hiroshi ; Itoh, Mitsuyasu ; Funahashi, Hiroomi ; Nagasaka, Akio. / Expression of erbB receptors mRNA in thyroid tissues. In: Biochimica et Biophysica Acta - General Subjects. 2004 ; Vol. 1673, No. 3. pp. 194-200.
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Kato, S, Kobayashi, T, Yamada, K, Nishii, K, Sawada, H, Ishiguro, H, Itoh, M, Funahashi, H & Nagasaka, A 2004, 'Expression of erbB receptors mRNA in thyroid tissues', Biochimica et Biophysica Acta - General Subjects, vol. 1673, no. 3, pp. 194-200. https://doi.org/10.1016/j.bbagen.2004.04.016

Expression of erbB receptors mRNA in thyroid tissues. / Kato, Seiya; Kobayashi, Takako; Yamada, Kouji; Nishii, Kazuhiro; Sawada, Hirohide; Ishiguro, Hiroshi; Itoh, Mitsuyasu; Funahashi, Hiroomi; Nagasaka, Akio.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1673, No. 3, 04.08.2004, p. 194-200.

Research output: Contribution to journalArticle

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