TY - JOUR
T1 - Expression of erbB receptors mRNA in thyroid tissues
AU - Kato, Seiya
AU - Kobayashi, Takako
AU - Yamada, Kouji
AU - Nishii, Kazuhiro
AU - Sawada, Hirohide
AU - Ishiguro, Hiroshi
AU - Itoh, Mitsuyasu
AU - Funahashi, Hiroomi
AU - Nagasaka, Akio
N1 - Funding Information:
This study was supported by a grant-in aid to Fujita Health University.
PY - 2004/8/4
Y1 - 2004/8/4
N2 - ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan. ErbB2 is associated with aggressive cancers and is used as a biological marker for the disease; Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) analyses have shown it to be increased in Graves' disease. Additional studies indicated a similar result in papillary carcinoma cells; mRNAs of erbB2 and erbB3 were increased but erbB4 mRNA was decreased, suggesting distorted erbB expression may be associated with tumorigenesis. However, only erbB2 overexpression is associated with Graves' disease. These data further implicate transmembrane-type receptors in tumorigenesis in the thyroid.
AB - ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan. ErbB2 is associated with aggressive cancers and is used as a biological marker for the disease; Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) analyses have shown it to be increased in Graves' disease. Additional studies indicated a similar result in papillary carcinoma cells; mRNAs of erbB2 and erbB3 were increased but erbB4 mRNA was decreased, suggesting distorted erbB expression may be associated with tumorigenesis. However, only erbB2 overexpression is associated with Graves' disease. These data further implicate transmembrane-type receptors in tumorigenesis in the thyroid.
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U2 - 10.1016/j.bbagen.2004.04.016
DO - 10.1016/j.bbagen.2004.04.016
M3 - Article
C2 - 15279891
AN - SCOPUS:3242745266
SN - 0304-4165
VL - 1673
SP - 194
EP - 200
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - 3
ER -