Expression of estrogen receptor-β in the postischemic monkey hippocampus

Noriko Takahashi; Anton B. Tonchev; Koji Koike; Kouichi Murakami; Kiyofumi Yamada; Tetsumori Yamashima; Masaki Inoue

doi:10.1016/j.neulet.2004.07.042

Expression of estrogen receptor-β in the postischemic monkey hippocampus

Noriko Takahashi, Anton B. Tonchev, Koji Koike, Kouichi Murakami, Kiyofumi Yamada, Tetsumori Yamashima, Masaki Inoue

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The molecular basis of estrogen-mediated neuroprotection against brain ischemia remains obscure. Here, we studied by immunohistochemistry the expression of estrogen receptor (ER) α and β in the hippocampal CA1 sector of postischemic adult macaque monkeys. ERβ was present in control CA1 pyramidal neurons, decreasing on day 4 after ischemia. In contrast, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1, where it was present in astrocytes and microglia. ERα was negligible in both control and postischemic monkeys. These results indicate that ERβ is the major receptor responsible for the direct estrogen actions on the monkey hippocampus, regulating glial response after ischemia.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	Neuroscience Letters
Volume	369
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2004.07.042
Publication status	Published - 07-10-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Access to Document

10.1016/j.neulet.2004.07.042

Cite this

@article{fdc69b85ce2c4c6a8d49d78d88b7def2,

title = "Expression of estrogen receptor-β in the postischemic monkey hippocampus",

abstract = "The molecular basis of estrogen-mediated neuroprotection against brain ischemia remains obscure. Here, we studied by immunohistochemistry the expression of estrogen receptor (ER) α and β in the hippocampal CA1 sector of postischemic adult macaque monkeys. ERβ was present in control CA1 pyramidal neurons, decreasing on day 4 after ischemia. In contrast, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1, where it was present in astrocytes and microglia. ERα was negligible in both control and postischemic monkeys. These results indicate that ERβ is the major receptor responsible for the direct estrogen actions on the monkey hippocampus, regulating glial response after ischemia.",

author = "Noriko Takahashi and Tonchev, {Anton B.} and Koji Koike and Kouichi Murakami and Kiyofumi Yamada and Tetsumori Yamashima and Masaki Inoue",

year = "2004",

month = oct,

day = "7",

doi = "10.1016/j.neulet.2004.07.042",

language = "English",

volume = "369",

pages = "9--13",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Expression of estrogen receptor-β in the postischemic monkey hippocampus

AU - Takahashi, Noriko

AU - Tonchev, Anton B.

AU - Koike, Koji

AU - Murakami, Kouichi

AU - Yamada, Kiyofumi

AU - Yamashima, Tetsumori

AU - Inoue, Masaki

PY - 2004/10/7

Y1 - 2004/10/7

N2 - The molecular basis of estrogen-mediated neuroprotection against brain ischemia remains obscure. Here, we studied by immunohistochemistry the expression of estrogen receptor (ER) α and β in the hippocampal CA1 sector of postischemic adult macaque monkeys. ERβ was present in control CA1 pyramidal neurons, decreasing on day 4 after ischemia. In contrast, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1, where it was present in astrocytes and microglia. ERα was negligible in both control and postischemic monkeys. These results indicate that ERβ is the major receptor responsible for the direct estrogen actions on the monkey hippocampus, regulating glial response after ischemia.

AB - The molecular basis of estrogen-mediated neuroprotection against brain ischemia remains obscure. Here, we studied by immunohistochemistry the expression of estrogen receptor (ER) α and β in the hippocampal CA1 sector of postischemic adult macaque monkeys. ERβ was present in control CA1 pyramidal neurons, decreasing on day 4 after ischemia. In contrast, ERβ immunoreactivity increased remarkably in the radiate and molecular layers of CA1, where it was present in astrocytes and microglia. ERα was negligible in both control and postischemic monkeys. These results indicate that ERβ is the major receptor responsible for the direct estrogen actions on the monkey hippocampus, regulating glial response after ischemia.

UR - http://www.scopus.com/inward/record.url?scp=5644254585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644254585&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.07.042

DO - 10.1016/j.neulet.2004.07.042

M3 - Article

C2 - 15380298

AN - SCOPUS:5644254585

SN - 0304-3940

VL - 369

SP - 9

EP - 13

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Expression of estrogen receptor-β in the postischemic monkey hippocampus

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this