Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma

Chihiro Minatsuki, Nobutake Yamamichi, Ken ichi Inada, Yu Takahashi, Kohei Sakurai, Takeshi Shimamoto, Yosuke Tsuji, Kazuya Shiogama, Shinya Kodashima, Yoshiki Sakaguchi, Keiko Niimi, Satoshi Ono, Toru Niwa, Ken Ohata, Nobuyuki Matsuhashi, Masao Ichinose, Mitsuhiro Fujishiro, Yutaka Tsutsumi, Kazuhiko Koike

Research output: Contribution to journalArticle

Abstract

Background: Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed. Aims: In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features. Methods: We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed. Results: The 68 patients consisted of 46 men (68%) and 22 women (32%) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57%) and 29 early-stage adenocarcinomas (43%). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6. Conclusions: Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.

Original languageEnglish
Pages (from-to)2617-2625
Number of pages9
JournalDigestive Diseases and Sciences
Volume63
Issue number10
DOIs
Publication statusPublished - 01-10-2018

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Stomach
Adenocarcinoma
Neoplasms
Adenoma
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Minatsuki, Chihiro ; Yamamichi, Nobutake ; Inada, Ken ichi ; Takahashi, Yu ; Sakurai, Kohei ; Shimamoto, Takeshi ; Tsuji, Yosuke ; Shiogama, Kazuya ; Kodashima, Shinya ; Sakaguchi, Yoshiki ; Niimi, Keiko ; Ono, Satoshi ; Niwa, Toru ; Ohata, Ken ; Matsuhashi, Nobuyuki ; Ichinose, Masao ; Fujishiro, Mitsuhiro ; Tsutsumi, Yutaka ; Koike, Kazuhiko. / Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. In: Digestive Diseases and Sciences. 2018 ; Vol. 63, No. 10. pp. 2617-2625.
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abstract = "Background: Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed. Aims: In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features. Methods: We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed. Results: The 68 patients consisted of 46 men (68{\%}) and 22 women (32{\%}) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57{\%}) and 29 early-stage adenocarcinomas (43{\%}). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6. Conclusions: Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.",
author = "Chihiro Minatsuki and Nobutake Yamamichi and Inada, {Ken ichi} and Yu Takahashi and Kohei Sakurai and Takeshi Shimamoto and Yosuke Tsuji and Kazuya Shiogama and Shinya Kodashima and Yoshiki Sakaguchi and Keiko Niimi and Satoshi Ono and Toru Niwa and Ken Ohata and Nobuyuki Matsuhashi and Masao Ichinose and Mitsuhiro Fujishiro and Yutaka Tsutsumi and Kazuhiko Koike",
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Minatsuki, C, Yamamichi, N, Inada, KI, Takahashi, Y, Sakurai, K, Shimamoto, T, Tsuji, Y, Shiogama, K, Kodashima, S, Sakaguchi, Y, Niimi, K, Ono, S, Niwa, T, Ohata, K, Matsuhashi, N, Ichinose, M, Fujishiro, M, Tsutsumi, Y & Koike, K 2018, 'Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma', Digestive Diseases and Sciences, vol. 63, no. 10, pp. 2617-2625. https://doi.org/10.1007/s10620-018-5179-0

Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. / Minatsuki, Chihiro; Yamamichi, Nobutake; Inada, Ken ichi; Takahashi, Yu; Sakurai, Kohei; Shimamoto, Takeshi; Tsuji, Yosuke; Shiogama, Kazuya; Kodashima, Shinya; Sakaguchi, Yoshiki; Niimi, Keiko; Ono, Satoshi; Niwa, Toru; Ohata, Ken; Matsuhashi, Nobuyuki; Ichinose, Masao; Fujishiro, Mitsuhiro; Tsutsumi, Yutaka; Koike, Kazuhiko.

In: Digestive Diseases and Sciences, Vol. 63, No. 10, 01.10.2018, p. 2617-2625.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma

AU - Minatsuki, Chihiro

AU - Yamamichi, Nobutake

AU - Inada, Ken ichi

AU - Takahashi, Yu

AU - Sakurai, Kohei

AU - Shimamoto, Takeshi

AU - Tsuji, Yosuke

AU - Shiogama, Kazuya

AU - Kodashima, Shinya

AU - Sakaguchi, Yoshiki

AU - Niimi, Keiko

AU - Ono, Satoshi

AU - Niwa, Toru

AU - Ohata, Ken

AU - Matsuhashi, Nobuyuki

AU - Ichinose, Masao

AU - Fujishiro, Mitsuhiro

AU - Tsutsumi, Yutaka

AU - Koike, Kazuhiko

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed. Aims: In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features. Methods: We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed. Results: The 68 patients consisted of 46 men (68%) and 22 women (32%) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57%) and 29 early-stage adenocarcinomas (43%). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6. Conclusions: Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.

AB - Background: Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed. Aims: In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features. Methods: We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed. Results: The 68 patients consisted of 46 men (68%) and 22 women (32%) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57%) and 29 early-stage adenocarcinomas (43%). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6. Conclusions: Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.

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U2 - 10.1007/s10620-018-5179-0

DO - 10.1007/s10620-018-5179-0

M3 - Article

VL - 63

SP - 2617

EP - 2625

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 10

ER -