Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma

Chihiro Minatsuki, Nobutake Yamamichi, Ken ichi Inada, Yu Takahashi, Kouhei Sakurai, Takeshi Shimamoto, Yosuke Tsuji, Kazuya Shiogama, Shinya Kodashima, Yoshiki Sakaguchi, Keiko Niimi, Satoshi Ono, Toru Niwa, Ken Ohata, Nobuyuki Matsuhashi, Masao Ichinose, Mitsuhiro Fujishiro, Yutaka Tsutsumi, Kazuhiko Koike

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Abstract

Background: Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed. Aims: In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features. Methods: We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed. Results: The 68 patients consisted of 46 men (68%) and 22 women (32%) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57%) and 29 early-stage adenocarcinomas (43%). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6. Conclusions: Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.

Original languageEnglish
Pages (from-to)2617-2625
Number of pages9
JournalDigestive Diseases and Sciences
Volume63
Issue number10
DOIs
Publication statusPublished - 01-10-2018

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

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    Minatsuki, C., Yamamichi, N., Inada, K. I., Takahashi, Y., Sakurai, K., Shimamoto, T., Tsuji, Y., Shiogama, K., Kodashima, S., Sakaguchi, Y., Niimi, K., Ono, S., Niwa, T., Ohata, K., Matsuhashi, N., Ichinose, M., Fujishiro, M., Tsutsumi, Y., & Koike, K. (2018). Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. Digestive Diseases and Sciences, 63(10), 2617-2625. https://doi.org/10.1007/s10620-018-5179-0