Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma

Yasuhiro Ito, Shigeki Higashiyama, Tsutomu Takeda, Yasuko Yamamoto, Ken ichi Wakasa, Nariaki Matsuura

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background. Previous studies demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) contributes to carcinogenesis and carcinoma progression. In this study, we investigated its expression in human pancreatic adenocarcinoma. Methods. We immunohistochemically investigated the expression of HB-EGF in 40 cases of pancreatic adenocarcinoma. Results. HB-EGF was only occasionally and faintly expressed in normal and hyperplastic pancreas duct epithelia. In pancreatic adenocarcinoma, 22 (55.0%) of the 40 cases were classified as positive for HB-EGF. Its expression was more frequently observed in cases with a low Ki-67 labeling index, well differentiated, early stage, small size, without lymph node metastasis and low EGF-R expression. Conclusion. These results suggest that HB-EGF mainly plays a role in early phase of the progression of pancreatic adenocarcinoma.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Pancreatology
Volume29
Issue number1
DOIs
Publication statusPublished - 01-01-2001
Externally publishedYes

Fingerprint

Epidermal Growth Factor
Heparin
Intercellular Signaling Peptides and Proteins
Adenocarcinoma
Pancreas
Carcinogenesis
Epithelium
Lymph Nodes
Neoplasm Metastasis
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Endocrinology
  • Gastroenterology

Cite this

Ito, Yasuhiro ; Higashiyama, Shigeki ; Takeda, Tsutomu ; Yamamoto, Yasuko ; Wakasa, Ken ichi ; Matsuura, Nariaki. / Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma. In: International Journal of Pancreatology. 2001 ; Vol. 29, No. 1. pp. 47-52.
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Expression of heparin-binding epidermal growth factor-like growth factor in pancreatic adenocarcinoma. / Ito, Yasuhiro; Higashiyama, Shigeki; Takeda, Tsutomu; Yamamoto, Yasuko; Wakasa, Ken ichi; Matsuura, Nariaki.

In: International Journal of Pancreatology, Vol. 29, No. 1, 01.01.2001, p. 47-52.

Research output: Contribution to journalArticle

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AU - Ito, Yasuhiro

AU - Higashiyama, Shigeki

AU - Takeda, Tsutomu

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AU - Wakasa, Ken ichi

AU - Matsuura, Nariaki

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AB - Background. Previous studies demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) contributes to carcinogenesis and carcinoma progression. In this study, we investigated its expression in human pancreatic adenocarcinoma. Methods. We immunohistochemically investigated the expression of HB-EGF in 40 cases of pancreatic adenocarcinoma. Results. HB-EGF was only occasionally and faintly expressed in normal and hyperplastic pancreas duct epithelia. In pancreatic adenocarcinoma, 22 (55.0%) of the 40 cases were classified as positive for HB-EGF. Its expression was more frequently observed in cases with a low Ki-67 labeling index, well differentiated, early stage, small size, without lymph node metastasis and low EGF-R expression. Conclusion. These results suggest that HB-EGF mainly plays a role in early phase of the progression of pancreatic adenocarcinoma.

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