Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway

Ryosuke Katsuyama; Ayako Morioka; Shogo Oka; Toshisuke Kawasaki

doi:10.1006/bbrc.2001.4263

Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway

Ryosuke Katsuyama, Ayako Morioka, Shogo Oka, Toshisuke Kawasaki

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found that the expression of M-ASGP-BP mRNA in bone marrow cells was induced during the differentiation into macrophages. To investigate the mechanism by which M-ASGP-BP mRNA expression is induced, we used U937 cells as a model. Treatment of U937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in M-ASGP-BP mRNA expression within 6 h. This induction was completely inhibited by PKC inhibitors, calphostin C, and staurosporine. Furthermore, MAP kinase inhibitors PD98059, but not SB202190, blocked M-ASGP-BP mRNA expression. These data indicate that M-ASGP-BP mRNA expression occurs through the activation of PKC and the MAPK classical pathway in the course of cell differentiation into macrophages.

Original language	English
Pages (from-to)	1269-1273
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	280
Issue number	5
DOIs	https://doi.org/10.1006/bbrc.2001.4263
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.2001.4263

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title = "Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway",

abstract = "Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found that the expression of M-ASGP-BP mRNA in bone marrow cells was induced during the differentiation into macrophages. To investigate the mechanism by which M-ASGP-BP mRNA expression is induced, we used U937 cells as a model. Treatment of U937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in M-ASGP-BP mRNA expression within 6 h. This induction was completely inhibited by PKC inhibitors, calphostin C, and staurosporine. Furthermore, MAP kinase inhibitors PD98059, but not SB202190, blocked M-ASGP-BP mRNA expression. These data indicate that M-ASGP-BP mRNA expression occurs through the activation of PKC and the MAPK classical pathway in the course of cell differentiation into macrophages.",

author = "Ryosuke Katsuyama and Ayako Morioka and Shogo Oka and Toshisuke Kawasaki",

year = "2001",

doi = "10.1006/bbrc.2001.4263",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway

AU - Katsuyama, Ryosuke

AU - Morioka, Ayako

AU - Oka, Shogo

AU - Kawasaki, Toshisuke

PY - 2001

Y1 - 2001

N2 - Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found that the expression of M-ASGP-BP mRNA in bone marrow cells was induced during the differentiation into macrophages. To investigate the mechanism by which M-ASGP-BP mRNA expression is induced, we used U937 cells as a model. Treatment of U937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in M-ASGP-BP mRNA expression within 6 h. This induction was completely inhibited by PKC inhibitors, calphostin C, and staurosporine. Furthermore, MAP kinase inhibitors PD98059, but not SB202190, blocked M-ASGP-BP mRNA expression. These data indicate that M-ASGP-BP mRNA expression occurs through the activation of PKC and the MAPK classical pathway in the course of cell differentiation into macrophages.

AB - Macrophage asialoglycoprotein-binding protein (M-ASGP-BP) is a Gal/GalNAc-specific lectin, which functions as an endocytosis receptor. We found that the expression of M-ASGP-BP mRNA in bone marrow cells was induced during the differentiation into macrophages. To investigate the mechanism by which M-ASGP-BP mRNA expression is induced, we used U937 cells as a model. Treatment of U937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in M-ASGP-BP mRNA expression within 6 h. This induction was completely inhibited by PKC inhibitors, calphostin C, and staurosporine. Furthermore, MAP kinase inhibitors PD98059, but not SB202190, blocked M-ASGP-BP mRNA expression. These data indicate that M-ASGP-BP mRNA expression occurs through the activation of PKC and the MAPK classical pathway in the course of cell differentiation into macrophages.

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ER -

Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway

Abstract

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