Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada, Toru Takano, Yasuhiro Ito, Fumio Matsuzuka, Akihiro Miya, Kaoru Kobayashi, Hiroshi Yoshida, Mikio Watanabe, Yoshinori Iwatani, Akira Miyauchi

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Abstract

Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalCancer Letters
Volume280
Issue number1
DOIs
Publication statusPublished - 18-07-2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yamada, H., Takano, T., Ito, Y., Matsuzuka, F., Miya, A., Kobayashi, K., Yoshida, H., Watanabe, M., Iwatani, Y., & Miyauchi, A. (2009). Expression of nestin mRNA is a differentiation marker in thyroid tumors. Cancer Letters, 280(1), 61-64. https://doi.org/10.1016/j.canlet.2009.02.006