Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada; Toru Takano; Yasuhiro Ito; Fumio Matsuzuka; Akihiro Miya; Kaoru Kobayashi; Hiroshi Yoshida; Mikio Watanabe; Yoshinori Iwatani; Akira Miyauchi

doi:10.1016/j.canlet.2009.02.006

Expression of nestin mRNA is a differentiation marker in thyroid tumors

Hiroya Yamada
, Toru Takano
, Yasuhiro Ito
, Fumio Matsuzuka
, Akihiro Miya
, Kaoru Kobayashi
, Hiroshi Yoshida
, Mikio Watanabe
, Yoshinori Iwatani
, Akira Miyauchi

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	Cancer Letters
Volume	280
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.02.006
Publication status	Published - 18-07-2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.canlet.2009.02.006

Cite this

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title = "Expression of nestin mRNA is a differentiation marker in thyroid tumors",

abstract = "Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.",

author = "Hiroya Yamada and Toru Takano and Yasuhiro Ito and Fumio Matsuzuka and Akihiro Miya and Kaoru Kobayashi and Hiroshi Yoshida and Mikio Watanabe and Yoshinori Iwatani and Akira Miyauchi",

note = "Funding Information: This research was supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, a Grant-in-Aid for Scientific Research C, 2008-2010, No.20590570, and a Research Grant of the Princess Takamatsu Cancer Research Fund 04-23606 of Japan.",

year = "2009",

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doi = "10.1016/j.canlet.2009.02.006",

language = "English",

volume = "280",

pages = "61--64",

journal = "Cancer Letters",

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publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Expression of nestin mRNA is a differentiation marker in thyroid tumors

AU - Yamada, Hiroya

AU - Takano, Toru

AU - Ito, Yasuhiro

AU - Matsuzuka, Fumio

AU - Miya, Akihiro

AU - Kobayashi, Kaoru

AU - Yoshida, Hiroshi

AU - Watanabe, Mikio

AU - Iwatani, Yoshinori

AU - Miyauchi, Akira

N1 - Funding Information: This research was supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, a Grant-in-Aid for Scientific Research C, 2008-2010, No.20590570, and a Research Grant of the Princess Takamatsu Cancer Research Fund 04-23606 of Japan.

PY - 2009/7/18

Y1 - 2009/7/18

N2 - Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

AB - Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.

UR - https://www.scopus.com/pages/publications/67349246764

UR - https://www.scopus.com/pages/publications/67349246764#tab=citedBy

U2 - 10.1016/j.canlet.2009.02.006

DO - 10.1016/j.canlet.2009.02.006

M3 - Article

C2 - 19268442

AN - SCOPUS:67349246764

SN - 0304-3835

VL - 280

SP - 61

EP - 64

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Expression of nestin mRNA is a differentiation marker in thyroid tumors

Abstract

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