Expression of ret finger protein correlates with outcomes in endometrial cancer

Hirohisa Tsukamoto, Takuya Kato, Atsushi Enomoto, Nobuhisa Nakamura, Yohei Shimono, Mayumi Jijiwa, Naoya Asai, Yoshiki Murakumo, Kiyosumi Shibata, Fumitaka Kikkawa, Masahide Takahashi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Ret finger protein (RFP) is a nuclear protein with transcriptional repressive activity that is highly expressed in a variety of human and rodent tumor cell lines. We examined the expression of RFP in human endometrial cancer and assessed its clinical significance. Formalin-fixed, paraffin-embedded sections from endometrial cancer tissues were immunostained with the RFP antibody, and the staining intensity was evaluated. The clinicopathological factors examined were age, International Federation of Gynecology and Obstetrics stage, tumor grade, myometrial invasion, and pelvic lymph node metastasis. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis. Of the 119 cancer tissues, 57 (47.9%) cases were positive for RFP immunoreactivity. RFP expression was not associated with any of the clinicopathological parameters examined. However, positive RFP expression significantly predicted poorer OS and PFS compared with negative expression (OS, P = 0.0011; PFS, P < 0.0001). In the multivariate analyses, positive RFP expression was an independent prognostic factor for survival in this study. RFP knockdown significantly impaired cancer cell migration and invasion in vitro with concomitant decreases of integrins β1 and α2. Positive RFP expression is a predictive marker for an unfavorable clinical outcome in patients with endometrial cancer. (Cancer Sci 2009; 100: 1895-1901).

Original languageEnglish
Pages (from-to)1895-1901
Number of pages7
JournalCancer science
Volume100
Issue number10
DOIs
Publication statusPublished - 10-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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